TY - JOUR T1 - Do Choroidal Melanocytes Affect Choroidal Thickness in Patients with Newly Diagnosed Vitiligo? TT - Vitiligo Tanısı Yeni Konulan Hastalarda Koroid Melanositleri Koroid Kalınlıklarını Etkiler mi? AU - Demirci, Göktuğ AU - Tükenmez Demirci, Gülşen AU - Karaman Erdur, Sevil AU - Tanrıverdi, Cafer PY - 2022 DA - December Y2 - 2022 DO - 10.29058/mjwbs.1122056 JF - Medical Journal of Western Black Sea JO - Med J West Black Sea PB - Zonguldak Bulent Ecevit University WT - DergiPark SN - 2822-4302 SP - 404 EP - 409 VL - 6 IS - 3 LA - en AB - Aim: Vitiligo is a chronic skin disease and considered to be an autoimmune, neural, and autocytotoxicpathophysiology in which mainly the melanocytes in the epidermis are focused and destroyed.Therefore, alterations in the choroid and retinal pigment epithelium are expected, and there are veryfew publications using modern technology in research of this subject.This study aimed to examine the optic disc, retinal nerve fiber layer (RNFL), and choroidal thicknessin patients with vitiligo by spectral-domain optical coherence tomography (SD-OCT) as a prospectiveobservational study.Material and Methods: This single-center prospective cross-sectional study included 40 eyes of 40patients with vitiligo and 42 eyes of 42 healthy individuals. The RNFL thickness, choroidal thickness,and optic disc parameters (rim area, disc area, and cup volume) were compared between the twogroups.Results: The study consisted of 21 female and 19 male in the vitiligo group, and 21 female and 21male in controls; no difference was found in gender distribution between two groups (p=0.836). Vitiligoand control groups had similar optic disc parameters, and RNFL and choroidal thicknesses; so thedifferences in the mentioned parameters did not differ statistically (p>0.05 for all).Conclusion: Vitiligo patients’ optic disc parameters, and RNFL and choroidal thicknesses did not differfrom those in healthy individuals. Based on unknown pathogenesis, the melanocytes at the choroidalregion may have compensatory mechanisms in vitiligo. KW - choroid KW - OCT KW - retina KW - vitiligo N2 - Amaç: Vitiligo, kronik bir deri hastalığıdır ve esas olarak epidermisteki melanositlerin hedef alındığı ve yok edildiği otoimmün, nöral ve otositotoksik bir patofizyoloji olarak kabul edilir. Bu nedenle koroidde ve retina pigment epitelinde değişiklikler beklenir ve bu konuda modern teknolojiyi kullanan çok az yayın mevcutturGereç ve Yöntem: Bu çalışmada vitiligolu hastalarda optik disk, retina sinir lifi tabakası (RSLT) ve koroid kalınlığının spektral alan optik koherens tomografi (SD-OKT) ile incelenmesi prospektif gözlemsel bu çalışma amaçlandı. Bu tek merkezli prospektif kesitsel çalışmaya vitiligolu 40 hastanın 40 gözü ve 42 sağlıklı bireyin 42 gözü dahil edildi. RSLT kalınlığı, koroid kalınlığı ve optik disk parametreleri (rim alanı, disk alanı ve cup hacmi) iki grup arasında karşılaştırıldı.Bulgular: Çalışmaya vitiligo grubunda 21 kadın ve 19 erkek, kontrol grubunda 21 kadın ve 21 erkek; iki grup arasında cinsiyet dağılımı açısından fark bulunmadı (p=0,836). Vitiligo ve kontrol gruplarında benzer optik disk parametreleri, RSLT ve koroid kalınlıkları; yani bahsedilen parametrelerdeki farklılıklar istatistiksel olarak farklı değildi (tümü için p>0.05).Sonuç: Vitiligo hastalarının optik disk parametreleri, RSLT ve koroid kalınlıkları sağlıklı bireylerden farklı değildi. Bilinmeyen bir patogeneze bağlı olarak, koroid bölgesindeki melanositlerin vitiligoda kendini telafi edici mekanizmaları olabilir. CR - 1 Alikhan A, Felsten LM, Daly M, et al. Vitiligo: acomprehensive overview part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. 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UR - https://doi.org/10.29058/mjwbs.1122056 L1 - https://dergipark.org.tr/en/download/article-file/2450223 ER -