TY  - JOUR
T1  - In the differential diagnosis of sepsis and hemophagocytic lymphohistiocytosis, procalcitonin and C-reactive protein (CRP) may be as determinant as ferritin
TT  - In the differential diagnosis of sepsis and hemophagocytic lymphohistiocytosis, procalcitonin and C-reactive protein (CRP) may be as determinant as ferritin
AU  - Oto, Arzu
AU  - Erdogan, Seher
AU  - Akbayram, Sinan
AU  - Bosnak, Mehmet
PY  - 2022
DA  - June
DO  - 10.5798/dicletip.1128911
JF  - Dicle Medical Journal
JO  - diclemedj
PB  - Dicle University
WT  - DergiPark
SN  - 1300-2945
SP  - 297
EP  - 307
VL  - 49
IS  - 2
LA  - en
AB  - Background: Hemophagocytic lymphohistiocytosis (HLH) and sepsis frequently appear as overlapping diagnoses in intensive care units. It is necessary to distinguish HLH, which has a very high mortality, from sepsis. In this study, we wanted to draw attention to the potential of procalcitonin (PCT) and C-Reactive Protein (CRP) as a marker like ferritin in differential diagnosis. Thus, HLH can be diagnosed as early as possible and the necessary aggressive immunosuppressive therapy can be added to the existing treatment.Methods: All of the patients in the sepsis clinic who meet the HLH criteria Group HLH; patients not meeting the HLH criteria were defined as Group non-HLH. Files of all patients were reviewed in regard to HLH diagnosis criteria and H score.Results: There were 16 patients in Group HLH and 15 in Group non-HLH. CRP and PCT levels were significantly lower (p: 0.007 and p
KW  - ferritin; Hemophagocytic lymphohistiocytosis
KW  - Children
KW  - procalcitonin; sepsis
CR  - 1.Henter JI, Horne A, Aricó M, et al. HLH‐2004:diagnostic and therapeutic guidelines forhemophagocytic lymphohistiocytosis. Pediatr BloodCancer. 2007;48(2):124-31.
CR  - 2.Goldstein B, Giroir B, Randolph A. Internationalpediatric sepsis consensus conference: definitionsfor sepsis and organ dysfunction in pediatrics.Pediatr Crit Care Med. 2005;6(1):2-8.
CR  - 3.Castell JV, Gómez‐lechón MJ, David M, et al. Acute‐phase response of human hepatocytes: regulation ofacute‐phase protein synthesis by interleukin‐6.Hepatology. 1990;12(5):1179-86.
CR  - 4.Uzzan B, Cohen R, Nicolas P, et al. Procalcitonin asa diagnostic test for sepsis in critically ill adults andafter surgery or trauma: a systematic review andmeta-analysis. Crit Care Med. 2006;34(7):1996-2003.
UR  - https://doi.org/10.5798/dicletip.1128911
L1  - https://dergipark.org.tr/en/download/article-file/2478890
ER  -