@article{article_1130028, title={Association between serum netrin-1 level and obesity-related markers in obese subjects}, journal={Mehmet Akif Ersoy University Journal of Health Sciences Institute}, volume={10}, pages={108–115}, year={2022}, DOI={10.24998/maeusabed.1130028}, author={Aydın Acar, Çiğdem and Aydın, Niyazi and Pehlivanoğlu, Suray and Kök, Mehmet}, keywords={Obesity, Netrin-1, ELISA, Biomarker}, abstract={Netrins are important signaling proteins that guide both neural and vascular development. Netrin-1 regulates many physiological processes such as cell proliferation, adhesion and migration. The aim of this study was to determine the association between serum netrin-1 level and biochemical parameters in obese subjects. Serum samples were collected from obese (n=15) and control (n=30) subjects. The serum netrin-1 levels were evaluated by ELISA. Variable data were compared by Mann Whitney U test and correlation was estimated by Spearman correlation analyses. The level of circulating netrin-1 protein was determined to be significantly lower in obese group compared to controls. The median value was 844.0 pg/mL in the control group and 338 pg/mL in the obese group (p <0.0001). Serum netrin-1 level was negatively correlated with HbA1c, LDL, cholesterol and triglyceride (P < 0.01). In addition, ROC curve analysis indicated that netrin-1 level could define the presence of obesity with AUC value of 0.8667 (95% Cl=0.7249-1.000; P <0.0001). Our study suggests that netrin-1 secretions are significantly reduced in obese subjects and negatively correlated with obesity markers. Therefore, netrin-1 can be evaluated as a possible potential biomarker for obesity.}, number={2}, publisher={Burdur Mehmet Akif Ersoy University}, organization={Burdur Mehmet Akif Ersoy University Scientific Research Rrojects Unit}