TY  - JOUR
T1  - Simultaneous Determination of Spiramycin and Metronidazole in Coated Tablets by Derivative and Wavelet Transforms of UV Spectra and Ratio Spectra
AU  - Xuan, Doan Thanh
AU  - Hoang, Vu Dang
PY  - 2022
DA  - October
JF  - Fabad Eczacılık Bilimler Dergisi
JO  - Fabad J Pharm Sci
PB  - FABAD Ankara Eczacılık Bilimleri Derneği
WT  - DergiPark
SN  - 1300-4182
SP  - 301
EP  - 316
VL  - 47
IS  - 3
LA  - en
AB  - Signal transformation (derivative and wavelet) was applied toUV spectra and ratio spectra to directly quantify spiramycin andmetronidazole in binary mixtures. Linear calibration graphs wereexamined for either drug in the concentration range of 6.25 – 25mg/L with R2 > 0.990. First derivative-transformed (i.e., usingSavitzky-Golay filter) and wavelet-transformed (i.e., using familiessuch as sym6, haar, db5, bior2.4, rbio2.4, meyr with scaling factor =256) UV spectrophotometric methods were statistically comparable tothe RP-HPLC reference method (p > 0.05) with regard to accuracyand precision when assaying spiramycin and metronidazole in theircoated tablets. These analytical methods used only green solvent, andproved to be time-saving and cost-effective.
KW  - UV spectrophotometry
KW  - derivative transform
KW  - wavelet
transform
KW  - spiramycin
KW  - metronidazole
KW  - coated tablets
KW  - RP-HPLC
CR  - Abdel-Kader, D. A., & Hashem, E. Y. (2021). Spectrophotometric determination of Metronidazole antibacterial drug via oxidation with alkaline potassium permanganate. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 259, 119858. doi:https://doi.org/10.1016/j.saa.2021.119858
UR  - https://dergipark.org.tr/en/pub/fabadeczacilik/issue//1134580
L1  - https://dergipark.org.tr/en/download/article-file/2502362
ER  -