TY  - JOUR
T1  - STEROIDOGENESIS PATHWAY AND BREAST CANCER: EMPOWERING PERSONALIZED TREATMENT WITH A METABOLOMICS APPROACH
TT  - STEROIDOGENESIS PATHWAY AND BREAST CANCER: EMPOWERING PERSONALIZED TREATMENT WITH A METABOLOMICS APPROACH
AU  - Tüzüner, Mete Bora
PY  - 2022
DA  - August
JF  - Journal of Advanced Research in Health Sciences
JO  - SABİAD
PB  - Istanbul University
WT  - DergiPark
SN  - 2651-4060
SP  - 25
EP  - 25
VL  - 5
IS  - S-1
LA  - en
AB  - The relationship between steroid hormones and breast cancer has been known for decades. Steroid hormones play an active role in cellular proliferation in this cancer type and show their mitogenic effects by binding to estrogen, progesterone, and androgen receptors. Reducing the concentrations of active hormones in the systemic circulation may be insufficient to prevent the progression of the cancer, as it will enable the selection of tumor/peripheral cells that synthesize active steroids from circulating steroid precursors. The intracrine capacity of breast tissues now also has become an emergent area of interest in metabolomic research. With the development of the current omics technologies, we are able to define and quantify small metabolic differences with precision not only from body fluids but tissues which can be associated with clinicopathological factors in early-stage invasive breast cancer cases. As our understanding grows about the regional steroid metabolism in breast cancer tissues, metabolomic biomarkers will be used more and more to shape the best way of personalized treatment approach of this deadly disease.
KW  - Steroid Hormone
KW  - Breast Cancer
KW  - Steroidogenesis Pathway
N2  - The relationship between steroid hormones and breast cancer has been known for decades. Steroid hormones play an active role in cellular proliferationin this cancer type and show their mitogenic effects by binding to estrogen, progesterone, and androgen receptors. Reducing the concentrations of activehormones in the systemic circulation may be insufficient to prevent the progression of the cancer, as it will enable the selection of tumor/peripheral cellsthat synthesize active steroids from circulating steroid precursors. The intracrine capacity of breast tissues now also has become an emergent area ofinterest in metabolomic research.With the development of the current omics technologies, we are able to define and quantify small metabolic differences with precision not only from bodyfluids but tissues which can be associated with clinicopathological factors in early-stage invasive breast cancer cases. As our understanding grows aboutthe regional steroid metabolism in breast cancer tissues, metabolomic biomarkers will be used more and more to shape the best way of personalizedtreatment approach of this deadly disease.
CR  - Grozescu T, Popa F. Prostate cancer between prognosis and adequate/proper therapy. J Med Life. 2017;10(1):5-12
UR  - https://dergipark.org.tr/en/pub/sabiad/issue//1136824
L1  - https://dergipark.org.tr/en/download/article-file/2511292
ER  -