TY  - JOUR
T1  - miR-3653-3P EXPRESSION IN PERIPHERAL BLOOD OF PATIENTS WITH OVARIAN CARCINOMA
TT  - miR-3653-3P EXPRESSION IN PERIPHERAL BLOOD OF PATIENTS WITH OVARIAN CARCINOMA
AU  - Pektopal Delek, Fatma Seher
AU  - Akdeniz Ödemiş, Demet
AU  - Şükrüoğlu Erdoğan, Özge
AU  - Kılıç Erciyas, Seda
AU  - Kurt, Büşra
AU  - Tunçer, Şeref Buğra
AU  - Yazıcı, Hülya
PY  - 2022
DA  - August
DO  - 10.26650/JARHS2021-1136829
JF  - Journal of Advanced Research in Health Sciences
JO  - SABİAD
PB  - Istanbul University
WT  - DergiPark
SN  - 2651-4060
SP  - 37
EP  - 37
VL  - 5
IS  - S-1
LA  - en
AB  - Ovarian cancer is a late-stage cancer with early and frequent recurrence, and there is still no effective treatment.There are no sensitive and specific biomarkers to be used effectively in the early diagnosis and treatment of the disease.Those currently used in the clinic are extremely insufficient for the early diagnosis and treatment follow-up of the disease, in terms of accurately determining the minimal residual disease.Many studies have shown that deregulation or dysfunction of miRNAs in the small non-coding RNA class contributes to cancer development However, it is known that the expressions of a number of miRNAs differ in ovarian cancer. Examining the expression patterns of known miRNAs in cancer research by comparing them between patients and healthy people is extremely important in terms of finding disease-specific biological markers, and determining the roles of these molecules in the pathogenesis of ovarian cancer is also significant.In the thesis study presented, the expression profile of miR-3653-3p was investigated in a control group consisting of 150 high-risk ovarian cancer patients and 100 healthy individuals, and both groups were compared with each other.It was found that the expression level of miR-3653-3p in the peripheral blood of ovarian cancer patients was 9.49 times higher than the control groups and the results were shown to be statistically significant(p = 0.00).In addition to these results, whether miR-3653-3p can be used as a non-invasive biomarker in peripheral blood for ovarian cancer was evaluated by ROC analysis and it was shown that the molecule in question was a statistically significant biomarker.
KW  - Ovarian carcinoma
KW  - miRNA expression
KW  - miR-3653-3p
KW  - biomarker
N2  - Ovarian cancer is a late-stage cancer with early and frequent recurrence, and there is still no effective treatment.There are no sensitive and specificbiomarkers to be used effectively in the early diagnosis and treatment of the disease.Those currently used in the clinic are extremely insufficient for theearly diagnosis and treatment follow-up of the disease, in terms of accurately determining the minimal residual disease.Many studies have shown thatderegulation or dysfunction of miRNAs in the small non-coding RNA class contributes to cancer development However, it is known that the expressions ofa number of miRNAs differ in ovarian cancer. Examining the expression patterns of known miRNAs in cancer research by comparing them between patientsand healthy people is extremely important in terms of finding disease-specific biological markers, and determining the roles of these molecules in thepathogenesis of ovarian cancer is also significant.In the thesis study presented, the expression profile of miR-3653-3p was investigated in a control groupconsisting of 150 high-risk ovarian cancer patients and 100 healthy individuals, and both groups were compared with each other.It was found that theexpression level of miR-3653-3p in the peripheral blood of ovarian cancer patients was 9.49 times higher than the control groups and the results wereshown to be statistically significant(p = 0.00).In addition to these results, whether miR-3653-3p can be used as a non-invasive biomarker in peripheral bloodfor ovarian cancer was evaluated by ROC analysis and it was shown that the molecule in question was a statistically significant biomarker.
CR  - Grozescu T, Popa F. Prostate cancer between prognosis and adequate/proper therapy. J Med Life. 2017;10(1):5-12
UR  - https://doi.org/10.26650/JARHS2021-1136829
L1  - https://dergipark.org.tr/en/download/article-file/2511320
ER  -