TY  - JOUR
T1  - S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA
TT  - S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA
AU  - Sanlav, Gamze
AU  - Baran, Burçin
AU  - Kızmazoğlu, Deniz
AU  - Kum Özşengezer, Selen
AU  - Aktaş, Safiye
AU  - Altun, Zekiye
AU  - Olgun, Nur
PY  - 2022
DA  - August
DO  - 10.26650/JARHS2021-1136890
JF  - Journal of Advanced Research in Health Sciences
JO  - SABİAD
PB  - Istanbul University
WT  - DergiPark
SN  - 2651-4060
SP  - 55
EP  - 55
VL  - 5
IS  - S-1
LA  - en
AB  - Objective: S-100 is an acidic-calcium-binding protein and was first described in cells of neuroendocrine origin. It plays an important role in various cellularprocesses such as cell differentiation and proliferation. S-100 is described to be a negative prognostic marker for the advanced stages of melanoma andwas evaluated to be prognostic biomarker for different cancers. Neuroblastoma(NB) is remarkable for its broad spectrum of clinical behavior, varying fromspontaneous regression to progressive disease and accounts for ~15% of childhood cancer‐related mortality. This diversity in behavior correlates closelywith defined clinical and biologic features and combinations of prognostic variables are used for risk-group assignment. The aim of this study is toinvestigate the S-100 expression levels among neuroblastoma patients and to determine if S-100 expression levels could be prognostic biomarker forneuroblastoma.Materials and Methods: Histological tumor sections of 40 cases of varying stages and risk groups of neuroblastoma were studied. The patients were stagedaccording to criteria defined by Turkish Pediatric Oncology Group and International Neuroblastoma Staging System(INSS). Risk groups were determinedaccording to the International Neuroblastoma Risk Group(INRG) classification system. S-100 protein expression levels were evaluated by immunohistochemicalstaining on paraffin sections of neuroblastoma patient tissue samples. All sections were independently and blindly studied for protein expression undermicroscopic examination. P values<0.05 was accepted statistically significant.Results: Schwann cells in the ganglioneuromas and ganglioneuroblastomas always strongly stained. Neuroblastoma cases with early stage and low-tointermediaterisk showed upregulated expression.Conclusion: While study is still ongoing, preliminary results showed that S-100 could be a candidate prognostic marker for neuroblastoma patients.
KW  - neuroblastoma
KW  - prognosis
KW  - s-100
KW  - biomarker
N2  - Objective: S-100 is an acidic-calcium-binding protein and was first described in cells of neuroendocrine origin. It plays an important role in various cellularprocesses such as cell differentiation and proliferation. S-100 is described to be a negative prognostic marker for the advanced stages of melanoma andwas evaluated to be prognostic biomarker for different cancers. Neuroblastoma(NB) is remarkable for its broad spectrum of clinical behavior, varying fromspontaneous regression to progressive disease and accounts for ~15% of childhood cancer‐related mortality. This diversity in behavior correlates closelywith defined clinical and biologic features and combinations of prognostic variables are used for risk-group assignment. The aim of this study is toinvestigate the S-100 expression levels among neuroblastoma patients and to determine if S-100 expression levels could be prognostic biomarker forneuroblastoma.Materials and Methods: Histological tumor sections of 40 cases of varying stages and risk groups of neuroblastoma were studied. The patients were stagedaccording to criteria defined by Turkish Pediatric Oncology Group and International Neuroblastoma Staging System(INSS). Risk groups were determinedaccording to the International Neuroblastoma Risk Group(INRG) classification system. S-100 protein expression levels were evaluated by immunohistochemicalstaining on paraffin sections of neuroblastoma patient tissue samples. All sections were independently and blindly studied for protein expression undermicroscopic examination. P values<0.05 was accepted statistically significant.Results: Schwann cells in the ganglioneuromas and ganglioneuroblastomas always strongly stained. Neuroblastoma cases with early stage and low-tointermediaterisk showed upregulated expression.Conclusion: While study is still ongoing, preliminary results showed that S-100 could be a candidate prognostic marker for neuroblastoma patients.
CR  - Arayıcı ME YF, Ellidokuz H. Importance of Cancer Registration and its Place in Cancer Control. Sted. 2021;30(5):366-75
UR  - https://doi.org/10.26650/JARHS2021-1136890
L1  - https://dergipark.org.tr/en/download/article-file/2511536
ER  -