@article{article_1137995, title={Candida strains and resistance patterns identified in a tertiary hospital}, journal={The European Research Journal}, volume={8}, pages={716–721}, year={2022}, DOI={10.18621/eurj.1137995}, author={Demir, Canan}, keywords={Candida, fungal infection, antifungal agents}, abstract={<p> <b>Objectives: </b> <i>Candida </i>species are the most common fungal infectious agents. <i>Candida </i> species are important with their increasing frequency in hospital-acquired infectious agents. The issue of antibiotic resistance, which frequently encountered in bacterial agents, is unfortunately also valid in fungal infections. In the present study, we aimed to determine the resistance of <i>Candida </i> species in our hospital including 1350 patient beds, the materials and units of production, and their sensitivity to antifungal drugs, in particular fluconazole. </p> <p> <b>Methods: </b>Yeast growths, colony morphology, germ tube formation and VITEK 2 Compact automated identification system detected in the samples evaluated in the central laboratory of our hospital between January 1, 2021 and December 31, 2021 were typed. Antifungal susceptibilities, especially fluconazole, caspofungin, and amphotericin B susceptibilities, were determined by an automated system. </p> <p> <b>
Results: </b> In total, 2446 within the <i>Candida </i> growing sample was determined as 49% <i>Candida albicans </i>, 26.9% <i>Candida parapsilosis </i>, %17.9 <i>Candida tropicalis </i>, <i>Candida glabrata </i>and <i>Candida krusei </i> were observed in 2.3%. Although the distribution of <i>Candida </i> species in other intensive care units and services was comparable to the general incidence, <i>C. albicans </i> was detected in 38%, <i>C. parapsilosis </i> 30% and <i>C. tropicalis </i> 27% in surgical intensive care units. Moreover, <i>C. tropicalis </i> was the dominant species in the neonatal intensive care unit (75%). </p> <p> <b>
Conclusions: </b> In the present study, <i>C. albicans </i> was the most common candida species, and <i>C. parapsilosis </i> was the second most frequently reproduced species. It has been suggested that resistance patterns differ between species and between wards, therefore species identification and susceptibility analysis are important, and these should be taken into account when starting empirical, preemptive and antifungal treatment. </p>}, number={5}, publisher={Prusa Medical Publishing}