TY  - JOUR
T1  - Changes in Treatment Adherence During the COVID-19 Pandemic in Patients with Severe Asthma Receiving  Biologic Agent Treatment
TT  - Biyolojik Ajan Tedavisi Alan Ağır Astımlı Hastalarda COVID-19  Pandemisi Sırasında Tedaviye Uyumdaki Değişiklikler
AU  - Ateş, Hale
AU  - Koca Kalkan, İlkay
AU  - Aksu, Kurtuluş
AU  - Topel, Musa
AU  - Yeşilkaya, Selma
AU  - Demir, Şenay
AU  - Nazik Bahçecioğlu, Sakine
PY  - 2022
DA  - September
Y2  - 2022
DO  - 10.16899/jcm.1168725
JF  - Journal of Contemporary Medicine
JO  - J Contemp Med
PB  - Rabia YILMAZ
WT  - DergiPark
SN  - 2667-7180
SP  - 678
EP  - 684
VL  - 12
IS  - 5
LA  - en
AB  - Aim: This study aimed to evaluate the effects of the COVID-19 pandemic on treatment adherence in patients with severe asthma who were receiving omalizumab and mepolizumab treatment in our clinic. Material and Method: A total of 53 patients with severe asthma, 45 of whom were using omalizumab and 8 of whom were using mepolizumab, were included in the study. The medical records of the patients were recorded anonymously and retrospectively. Results: It was seen that the rate of patients using omalizumab in the study population decreased during the pandemic period compared to the 1-year period before the pandemic. It was observed that approximately 51% of the patients using omalizumab missed routine treatment doses. The major factor in skipping treatment doses was the fear of contracting COVID-19 upon admission to the hospital. In the mepolizumab group, the rate of using biologic agents during the pandemic period increased compared to 1 year before the pandemic. Dose skipping was observed among 37.5% of the patients in this group and it was found that the major risk factor for skipping a dose was the fear of contracting COVID-19 upon admission to the hospital. Conclusion: In this study, it was found that there was a decrease in the duration and rate of use of biologic agent therapies administered in a health institution under the supervision of a healthcare professional among patients with severe asthma during the pandemic.
KW  - Coronavirus Anxiety Scale
KW  - Mepolizumab
KW  - Omalizumab
KW  - SARS-CoV-2
N2  - Amaç: Bu çalışmada, kliniğimizde omalizumab ve mepolizumab tedavisi alan ağır astımlı hastalarda COVID-19 pandemisinin tedaviye uyum üzerindeki etkilerinin değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Çalışmaya 45'i omalizumab ve 8'i mepolizumab kullanan ağır astımlı 53 hasta dahil edildi. Hastaların tıbbi kayıtları isimsiz ve geriye dönük olarak kaydedildi.Bulgular: Çalışma popülasyonunda omalizumab kullanan hasta oranının pandemi öncesi 1 yıllık döneme göre pandemi döneminde azaldığı görüldü. Omalizumab kullanan hastaların yaklaşık %51'inin rutin tedavi dozlarını kaçırdığı gözlendi. Tedavi dozlarının atlanmasındaki en büyük faktör, hastaneye kabul edildikten sonra COVID-19'a yakalanma korkusuydu. Mepolizumab grubunda pandemi döneminde biyolojik ajan kullanma oranı pandemi öncesi 1 yıl öncesine göre artış gösterdi. Bu gruptaki hastaların %37,5'inde doz atlama gözlemlendi ve doz atlamanın en büyük risk faktörünün hastaneye başvuruda COVID-19 kapma korkusu olduğu bulundu.Sonuç: Bu çalışmada, bir sağlık kuruluşunda sağlık profesyoneli gözetiminde uygulanan biyolojik ajan tedavilerinin pandemi döneminde ağır astımı olan hastalarda kullanım süre ve oranlarında azalma olduğu saptanmıştır.
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UR  - https://doi.org/10.16899/jcm.1168725
L1  - https://dergipark.org.tr/en/download/article-file/2623295
ER  -