@article{article_1174600, title={Protective Effects of Chlorella Vulgaris in Alcohol Intoxication}, journal={Eurasian Journal of Toxicology}, volume={4}, pages={73–78}, year={2022}, DOI={10.51262/ejtox.1174600}, author={Mecit, Tarık and Kamiloğlu, Nadide Nabil}, keywords={Ethyl alcohol, Chlorella vulgaris, GSH, GSH-Px, MAPK, MDA}, abstract={Objectives: The aim of the study, to investigate the effect of Chlorella vulgaris on the liver, kidney and heart MAPK (Mitogen-activated protein kinase), lipid peroxidation antioxidant enzyme activity with ethyl alcohol toxification. Materials and Methods: 10-12 monthly, weighing 200-250 gr, 24 adult male Sprague Dawley rats were used. Rats were divided into 3 (n=8) groups which 2 experiments and a control. 5mg/kg of isocaloric maltose was given to the control group by gavage. 15 g/kg ethyl alcohol diluted with 50% water was given to the alcohol group and 300 mg/kg C. vulgaris and then 15 g/kg ethyl alcohol diluted with 50% water were given to C. vulgaris group. At the end of the experiment tissue samples were taken. Blood samples were collected into EDTA tubes and the tissues were kept at -20°C. The blood and tissue samples were used to investigate the GSH/GSH-Px, MAPK activity and MDA levels. Results: MAPK activities in liver and lung tissue were increased with C. vulgaris which decrease with ethyl alcohol while MAPK activities in kidney and heart tissue decreased with C. vulgaris. The reduction in tissue GSH-Px levels with alcohol was increased significantly with C. vulgaris application (p <0.05). The declining GSH levels of liver and kidney tissue with alcohol were found to significantly increase with C. vulgaris (p <0.05). When tissue MDA levels of groups were compared, increasing MDA levels with alcohol in liver and heart tissues were determined to significantly decrease with C. vulgaris (p <0.001, p <0.05 respectively). Conclusion: As a conclusion, C. vulgaris increased antioxidant enzyme activity especially in liver tissues and decreased lipid peroxidation in tissue which arises with ethyl alcohol that was evaluated this effect has tissue protective activity of C. vulgaris. Also, increasing in liver tissue MAPK activities as a result of alcohol toxication was fixed with C. vulgaris. This situation may be associated with a protective effect on the intracellular enzyme system activity of C. vulgaris.}, number={3}, publisher={Acil Tıp Uzmanları Derneği}