@article{article_1186191, title={The Relationship between IL-1β [-31 T/C] Gene Polymorphism and Symptomatic Lumbar Disc Herniation}, journal={Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi}, volume={10}, pages={62–64}, year={2023}, DOI={10.47572/muskutd.1186191}, author={Çıtışlı, Veli and Koseler, Aylin}, keywords={Genotype, IL-1β Polymorphism, Lumbar Disc Herniation}, abstract={In this study, the relationship between IL-1β [-31 C / T] gene polymorphisms in the herniated lumbar disc is offered to be investigated. IL-1β [-31 C / T] gene was amplified by the PCR [Polymerase Chain Reaction] method. Polymorphic site cut with the restriction enzyme Alu I and genotyping were performed. Fifteen subjects (15%) were homozygous for the C/C allele at -31 position of IL-1β gene. Of the remaining 85 subjects, 64 (64%) were heterozygous for C/T and 21 (21%) were homozygous for T/T. In LDH group, fifteen subjects (30%) were homozygous for the T/T allele at -31 position of IL-1β gene. 35 subjects were heterozygous for C/T (70%). There were significant differences between control and LDH group. In LDH group, C/T and T/T genotype were higher than the control group, however in control group C / C genotype was higher. C/C genotype was not determined in LDH group. In this study, IL-1β -31T allele is shown to be associated with the Lumbar herniated disc.}, number={1}, publisher={Mugla Sitki Kocman University}, organization={The authors declared that this study received no financial support.}