TY - JOUR T1 - The association between vitamin D level and ICU mortality in COVID-19 patients: a single center survey AU - Onuk, Sevda AU - Eren, Esma PY - 2023 DA - March DO - 10.32322/jhsm.1198621 JF - Journal of Health Sciences and Medicine JO - J Health Sci Med /JHSM /jhsm PB - MediHealth Academy Yayıncılık WT - DergiPark SN - 2636-8579 SP - 336 EP - 341 VL - 6 IS - 2 LA - en AB - Aim: Vitamin D, an immune modulator, may contribute COVID-19 infection. This study aims to assess the relationship between vitamin D value and clinical outcomes (need for mechanical ventilation (MV) support and intensive care unit (ICU) mortality) in critically ill patients diagnosed with COVID-19.Material and Method: This study included critically ill adult patients diagnosed with COVID-19 infection. Serum vitamin D level was analyzed using liquid chromatography mass spectrometry. Vitamin D concentration was classified as normal (≥20 ng/mL) and deficiency (0.05).Conclusion: Approximately 70% of our study sample has below the normal range of serum vitamin D value. Low serum vitamin D concentrations were associated with increased SOFA, creatinine, and troponin concentrations in patients with COVID-19 infection. Vitamin D deficiency was not a predictor of need for MV support and ICU mortality in COVID-19 patients. KW - COVID-19 KW - vitamin D KW - intensive care unit KW - mortality CR - 1. Alhazzani W, Evans L, Alshamsi F, Møller MH, Ostermann M, Prescott HC, et al. Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update. Crit Care Med [Internet]. 2021 [cited 2022 Jul 16];49(3):E219–34. Available from: https://pubmed.ncbi.nlm.nih.gov/33555780/ CR - 2. Wu YC, Chen CS, Chan YJ. The outbreak of COVID-19: An overview. J Chin Med Assoc [Internet]. 2020 [cited 2022 Jul 16];83(3):217–20. Available from: https://pubmed.ncbi.nlm.nih.gov/32134861/ CR - 3. Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med [Internet]. 2020 Apr 30 [cited 2022 Jul 16];382(18):1708–20. Available from: https://pubmed.ncbi.nlm.nih.gov/32109013/ CR - 4. Shah K, Saxena D, Mavalankar D. Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis. QJM [Internet]. 2021 Mar 1 [cited 2022 Jul 16];114(3):175–81. Available from: https://pubmed.ncbi.nlm.nih.gov/33486522/ CR - 5. Pal R, Banerjee M, Bhadada SK, Shetty AJ, Singh B, Vyas A. Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis. J Endocrinol Invest [Internet]. 2022 Jan 1 [cited 2022 Jul 16];45(1):53–68. Available from: https://pubmed.ncbi.nlm.nih.gov/34165766/ CR - 6. Rawat D, Roy A, Maitra S, Shankar V, Khanna P, Baidya DK. “Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis.” Diabetes Metab Syndr [Internet]. 2021 Jul 1 [cited 2022 Jul 16];15(4). Available from: https://pubmed.ncbi.nlm.nih.gov/34217144/ CR - 7. Holick MF. Vitamin D deficiency. N Engl J Med [Internet]. 2007 [cited 2022 Jul 16];357(3):266–81. Available from: https://pubmed.ncbi.nlm.nih.gov/17634462/ CR - 8. Lohia P, Nguyen P, Patel N, Kapur S. Exploring the link between vitamin D and clinical outcomes in COVID-19. Am J Physiol Endocrinol Metab [Internet]. 2021 Mar 1 [cited 2022 Jul 16];320(3). Available from: https://pubmed.ncbi.nlm.nih.gov/33404354/ CR - 9. Hu Y, Kung JY, Cave A, Banh HL. Effects of Vitamin D Serum Level on Morbidity and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis. J Pharm Pharm Sci [Internet]. 2022 [cited 2022 Jul 16];25:84–92. Available from: https://pubmed.ncbi.nlm.nih.gov/35245430/ CR - 10. Wang Z, Joshi A, Leopold K, Jackson S, Christensen S, Nayfeh T, et al. Association of vitamin D deficiency with COVID-19 infection severity: Systematic review and meta-analysis. Clin Endocrinol (Oxf) [Internet]. 2022 Mar 1 [cited 2022 Jul 16];96(3):281–7. Available from: https://pubmed.ncbi.nlm.nih.gov/34160843/ CR - 11. Varikasuvu SR, Thangappazham B, Vykunta A, Duggina P, Manne M, Raj H, et al. COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Expert Rev Anti Infect Ther [Internet]. 2022 [cited 2022 Jul 16];20(6):907–13. Available from: https://pubmed.ncbi.nlm.nih.gov/35086394/ CR - 12. Annweiler G, Corvaisier M, Gautier J, Dubée V, Legrand E, Sacco G, et al. Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study. Nutrients [Internet]. 2020 Nov 1 [cited 2022 Jul 16];12(11):1–12. Available from: https://pubmed.ncbi.nlm.nih.gov/33147894/ CR - 13. Jain A, Chaurasia R, Sengar NS, Singh M, Mahor S, Narain S. Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers. Sci Rep [Internet]. 2020 Dec 1 [cited 2022 Jul 16];10(1). Available from: https://pubmed.ncbi.nlm.nih.gov/33214648/ CR - 14. Bassatne A, Basbous M, Chakhtoura M, El Zein O, Rahme M, El-Hajj Fuleihan G. The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis. Metabolism [Internet]. 2021 Jun 1 [cited 2022 Jul 16];119. Available from: https://pubmed.ncbi.nlm.nih.gov/33774074/ CR - 15. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA [Internet]. 2012 Jun 13 [cited 2022 Oct 20];307(23):2526–33. Available from: https://pubmed.ncbi.nlm.nih.gov/22797452/ CR - 16. Ben-Eltriki M, Hopefl R, Wright JM, Deb S. Association between Vitamin D Status and Risk of Developing Severe COVID-19 Infection: A Meta-Analysis of Observational Studies. J Am Nutr Assoc [Internet]. 2022 [cited 2022 Oct 20];41(7). Available from: https://pubmed.ncbi.nlm.nih.gov/34464543/ CR - 17. Yosef TM, Saleh SA, Ali SF, Ahmed AE. Vitamin D assessment in patients with COVID-19 virus and correlation with severity. Egypt J Intern Med [Internet]. 2022 Dec [cited 2022 Oct 20];34(1). Available from: https://pubmed.ncbi.nlm.nih.gov/35822077/ CR - 18. Zidrou C, Vasiliadis A V, Tsatlidou M, Sentona M, Vogiatzis S, Beletsiotis A. The Relationship Between Vitamin D Status and the Clinical Severity of COVID-19 Infection: A Retrospective Single-Center Analysis. Cureus [Internet]. 2022 Feb 19 [cited 2022 Oct 20];14(2). Available from: https://pubmed.ncbi.nlm.nih.gov/35371737/ CR - 19. Bushnaq T, Algethami F, Qadhi A, Mustafa R, Ghafouri K, Azhar W, et al. The Impact of Vitamin D Status on COVID-19 Severity among Hospitalized Patients in the Western Region of Saudi Arabia: A Retrospective Cross-Sectional Study. Int J Environ Res Public Health [Internet]. 2022 Feb 1 [cited 2022 Jul 16];19(3). Available from: https://pubmed.ncbi.nlm.nih.gov/35162923/ CR - 20. Radujkovic A, Hippchen T, Tiwari-Heckler S, Dreher S, Boxberger M, Merle U. Vitamin D Deficiency and Outcome of COVID-19 Patients. Nutrients [Internet]. 2020 [cited 2022 Jul 16];12(9):1–13. Available from: https://pubmed.ncbi.nlm.nih.gov/32927735/ CR - 21. Baktash V, Hosack T, Patel N, Shah S, Kandiah P, Van Den Abbeele K, et al. Vitamin D status and outcomes for hospitalised older patients with COVID-19. Postgrad Med J [Internet]. 2021 Jul 1 [cited 2022 Jul 16];97(1149):442–7. Available from: https://pubmed.ncbi.nlm.nih.gov/32855214/ CR - 22. Tentolouris N, Samakidou G, Eleftheriadou I, Tentolouris A, Jude EB. The effect of vitamin D supplementation on mortality and intensive care unit admission of COVID-19 patients. A systematic review, meta-analysis and meta-regression. Diabetes Metab Res Rev [Internet]. 2022 May 1 [cited 2022 Jul 16];38(4). Available from: https://pubmed.ncbi.nlm.nih.gov/34965318/ UR - https://doi.org/10.32322/jhsm.1198621 L1 - https://dergipark.org.tr/en/download/article-file/2747791 ER -