TY  - JOUR
T1  - Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization
AU  - Çetin, Meltem
AU  - Tunc, Elif Nur
AU  - Uğur Kaplan, Afife Büşra
AU  - Kılınboz, Yaşar Furkan
PY  - 2023
DA  - August
DO  - 10.26650/IstanbulJPharm.2023.1201106
JF  - İstanbul Journal of Pharmacy
JO  - iujp
PB  - Istanbul University
WT  - DergiPark
SN  - 2587-2087
SP  - 133
EP  - 139
VL  - 53
IS  - 2
LA  - en
AB  - Background and Aims: Epilepsy is one of the most disabling and most common neurological disorders, affecting approximately 65 million people of all age groups worldwide. When there is no response to monotherapy in the treatment of epilepsy, the combined use of Carbamazepine (CARBA) and Levetiracetam (LEV), which have different mechanisms of action, can be additive/synergistic and may be useful in the clinic. The aim of our study is to develop a fixed-dose combination (FDC)- nanoemulsion (NE) formulation containing CARBA and LEV for the treatment of epilepsy.Methods: Blank NE (BLNK-NE) and CARBA+LEV-FDC-NE formulations were prepared and carried out the in vitro characterization studies [morphological analysis, centrifugation test, droplet size (DS), polydispersity index (PDI), zeta potential (ZP), viscosity and pH measurements, FT-IR analysis, the percent entrapment efficiency (EE%), and in vitro release study].Results: The DS, PDI, pH, and ZP values for the BLNK-NE formulation were found to be 117.63±3.82 nm, 0.240±0.014, 4.62±0.03, and (-)26.07±3.04 mV, respectively. For the CARBA+LEV-FDC-NE formulation, the DS, PDI, pH, and ZP values were determined as 137.56±3.11 nm, 0.225±0.013, 4.60±0.06, and (-)21.62±0.29 mV, respectively. The EE% values obtained for CARBA+LEV-FDC-NE were 97.33±0.56% (for CARBA) and 96.73±0.91% (for LEV).Conclusion: The CARBA+LEV-FDC-NE formulation was successfully prepared. This formulation had suitable in vitro characterization results.
KW  - Carbamazepine
KW  - epilepsy
KW  - fixed-dose combination
KW  - levetiracetam
KW  - nanoemulsion
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UR  - https://doi.org/10.26650/IstanbulJPharm.2023.1201106
L1  - https://dergipark.org.tr/en/download/article-file/2758401
ER  -