TY  - JOUR
T1  - Effects of Long-Acting Methylphenidate Formulations and Atomoxetine on Cardiac Functions in Children with Attention Deficit And Hyperactivity Disorder
TT  - Dikkat Eksikliği ve Hiperaktivite Bozukluğu Olan Çocuklarda Kullanılan Uzun Etkili Metilfenidat Bileşiklerinin ve Atomoksetinin Kardiyak Fonksiyonlar Üzerindeki Etkileri
AU  - Mutlu Mıhçıoğlu, Ajda
AU  - Kara, Tayfun
PY  - 2023
DA  - February
Y2  - 2023
DO  - 10.53446/actamednicomedia.1215509
JF  - Acta Medica Nicomedia
JO  - Acta Med Nicomedia
PB  - Kocaeli University
WT  - DergiPark
SN  - 2717-8994
SP  - 98
EP  - 106
VL  - 6
IS  - 1
LA  - en
AB  - Objectives: Methylphenidate (MPH) and Atomoxetine (ATX) are most commonly prescribed for the treatment of Attention Deficit And Hyperactivity Disorder (ADHD). Despite their widespread use, there are concerns about their cardiovascular safety. In this study, we aimed to investigate the effects of ADHD medications on cardiac functions.Methods: Forty-six children with ADHD disorder using osmotic-release oral system methylphenidate (OROS-MPH), 46 using extended-release methylphenidate (ER-MPH), and 46 using ATX for at least six months were included in the patient groups. 46 children with normal cardiac findings were included as the control group. All participants were evaluated using a sociodemographic information form, physical examination, 12-channel electrocardiography (ECG), transthoracic 2D echocardiography, Doppler echocardiography, and tissue Doppler imaging (TDI).Results: Statistically significant differences were observed in terms of A wave velocity (p=0,002), E/A (p
KW  - methyphenidate
KW  - atomoxetine
KW  - tissue Doppler imaging
KW  - attention deficit and hyperactivity disorder
N2  - Amaç: Dikkat Eksikliği ve Hiperaktivite Bozukluğunun (DEHB) tedavisinde metilfenidat (MPH) ve atomoksetin (ATX) en yaygın olarak reçete edilen ilaçlardır. Yaygın kullanılmalarına rağmen, kardiyovasküler güvenilirlikleri hakkında endişeler vardır. Bu çalışmada DEHB ilaçlarının kardiyak fonksiyonlar üzerine etkilerini araştırmayı amaçladık.Yöntem: Hasta gruplarına 46 ozmotik-salınımlı oral sistem metilfenidat (OROS-MPH) kullanan hasta, 46 geç-salınımlı metilfenidat (ER-MPH) kullanan hasta ve en az altı aydır ATX kullanan 46 DEHB tanılı çocuk dahil edildi. Normal kardiyak bulguları olan 46 çocuk kontrol grubu olarak alındı. Tüm katılımcılar sosyodemografik bilgi formu, fizik muayene, 12 kanallı elektrokardiyografi (EKG), transtorasik 2D ekokardiyografi, Doppler ekokardiyografi ve doku Doppler görüntüleme (TDI) kullanılarak değerlendirildi.Bulgular: Gruplar arasında A dalga hızı, E/A ve E' septal parametrelerinde istatistiksel olarak anlamlı fark izlendi (p=0,002, p
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UR  - https://doi.org/10.53446/actamednicomedia.1215509
L1  - https://dergipark.org.tr/en/download/article-file/2816599
ER  -