TY  - JOUR
T1  - An investigation on the cytogenotoxic effects of a spurge species (Euphorbia grisophylla) with partial ethnomedical use in Turkey
AU  - İla, Hasan Basri
AU  - Polat, Sedat
PY  - 2023
DA  - March
JF  - Cukurova University Journal of Natural and Applied Sciences
JO  - CUNAS
PB  - Cukurova University
WT  - DergiPark
SN  - 2822-2938
SP  - 11
EP  - 26
VL  - 2
IS  - 1
LA  - en
AB  - The effects of the aqueous extract obtained from the aerial parts of Euphorbia grisophylla M.L.S.Khan, a herbaceous member of the Euphorbiaceae family, which is common in other parts of the world outside the Antarctic continent, on genotoxic, cytotoxic, and oxidative parameters were investigated. Experiments were carried out under short-term and in vitro conditions with sublethal concentrations of the test substance extract. According to the first results, the plant extract did not significantly affect the oxidative stress indicators in cell culture. Similarly, it increased the micronucleus ratio in lymphocytes insignificantly, but the concentration-effect relationship is significant in the 24-hour treatment. Again, the test substance did not induce an evident reversion-type mutation in the Ames test. However, the percentage of damaged cells in the Comet test and the genetic damage index increased significantly except for the lowest concentration. The cytotoxic effect observed in the context of the same pattern with these findings is remarkable. In conclusion, the slightly clastogenic and cytotoxic effect of Euphorbia grisophylla aqueous extract, not based on the oxidative attack, may provide a new projection for further research, like cancer therapy.
KW  - Euphorbia grisophylla
KW  - Cytogenotoxicity
KW  - Micronucleus (MN) test
KW  - Ames/Salmonella test
KW  - Comet assay
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UR  - https://dergipark.org.tr/en/pub/cunas/issue//1215929
L1  - https://dergipark.org.tr/en/download/article-file/2818391
ER  -