TY - JOUR T1 - Obezite Enfeksiyon Hastalığı Mıdır? TT - Is Obesity an Infectious Disease? AU - Yavuz, Esranur AU - Özyürek, Fatmanur AU - Pehlivan, Merve PY - 2023 DA - June JF - ERÜ Sağlık Bilimleri Fakültesi Dergisi JO - ERÜ Sağlık Bilimleri Fakültesi Dergisi PB - Erciyes University WT - DergiPark SN - 2147-9011 SP - 56 EP - 65 VL - 10 IS - 1 LA - tr AB - Dünyada yaygınlığı giderek artmakta olan obezite, çağın hastalıkları arasında en önemlilerinden biridir. Obezitenin yaygın olan tanımına göre; obezite, artan yağ kütlesinin yağsız kütleye göre çok fazla olmasıdır ve çeşitli hastalıkları beraberinde sürüklemesi sebebiyle endişe vericidir. Obezitenin vücutta sebep olduğu inflamasyonun, bulaşıcı olan bir hastalık gibi davranması ve vücutta inflamatuar bir yanıt oluşturması bu alanda yapılan çalışmaları yoğunlaştırmıştır. Bu derleme makalede; obezitenin bulaşıcı olmayan kronik bir hastalık olmasına rağmen vücutta oluşturduğu inflamasyonu ve dolayısıyla tahribatının sonuçları birlikte incelenecektir. KW - obezite KW - inflamasyon KW - inflamatuar cevap N2 - Obesity which has increasing prevalence in the world, is one of the most important diseases of the age. According to the common definition of obesity, that the increased fat mass is too much compared to the lean mass and it is alarming due to leading to various diseases. The fact that the inflammation caused by obesity in the body acts as a disease that is contagious, and the body's response is in the form of an inflammatory response has intensified studies in this area. In this review article, the destruction and consequences of obesity in the body, although it is a chronic disease that is not contagious, will be examined. CR - Caiado, F., Pietras, E. M., & Manz, M. G. (2021). Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection. Journal of Experimental Medi-cine, 218(5). https://doi.org/10.1084/jem.20201541 CR - Chait, A., & den Hartigh, LJ. (2020). Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Frontiers Cardiovas-cular Medicine, 7(22). https://doi.org/10.3389/fcvm.2020.00022 CR - Chen, Q., Wang, D., Gu, Y., Jiang, Z., & Zhou, Z. (2022). Tange-retin prevents obesity by modulating systemic inflamma-tion, fat browing, and gut microbiota in high-fat diet-induced obese C57BL/6 mice. The Journal of Nutritional Bi-ochemistry,101. https://doi.org/10.1016/j.jnutbio.2022.108943 CR - Console, L., Scalise, M., & Indiveri, C. (2019). Exosomes in inflammation and role as biomarkers. Clinica Chimica Acta, 488, 165-171. https://doi.org/10.1016/j.cca.2018.11.009 CR - Dludla, P. V., Nkambule, B. B., Jack, B., Mkandla, Z., Mutize, T., Silvestri, S., Orlando, P., Tiano, L., Louw J., & Mazibuko-Mbeje S. E. (2019). Inflammation and oxidative stress in an obese state and the protective effects of gallic acid. Nutri-tiens, 11(23), 1-29. https://doi.org/10.3390/nu11010023 CR - Eley, V. A., Thuzar, M., Navarro, S., Dodd, B. R., & Zundert, A. A. (2021). Obesity, metabolic syndrome, and inflammation: An update for anaesthetists caring for patients with obesity. Anaesthesia Critical Care & Pain Medicine, 40. https://doi.org/10.1016/j.accpm.2021.100947 CR - Fisk, H. L., Childs, C. E., Miles, E. A., Ayres, R., Noakes, P. S., Paras-Chavez, C., Kuda, O., Kopecký, J., Antoun, E., Lilly-crop, K. A., Calder, P. C. (2022). Modification of subcutane-ous white adipose tissue inflammation by omega-3 fatty ac-ids is limited in human obesity-a double blind, randomised clinical trial. eBioMedicine, 77. https://doi.org./10.1016/j.ebiom.2022.103909 CR - Hermsdorff, H. M., Zulet, M. A., Abete, I., Martínez, J. A. (2011). A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects. European Journal of Nutrition, 50(1), 9-61. https://doi.org./ 10.1007/s00394-010-0115-x CR - Izquierdo, A. G., Crujeiras, A. B., Casanueva, F. F., & Carreira, M. C. (2019). Leptin, obesity, and leptin resistance: Where are we. Nutrients, 11-22. https://doi.org/10.3390/nu11112704 CR - İnkaya, A. Ç. (2021). HIV enfeksiyonu ve inflamasyon. Türkiye Klinikleri, 1, 6-12. Jackisch, L., Kumsaiyai, W., Moore, J. D., Al-Daghri, N., Kyrou, I., Barber. T. M., Randeva, H., Kumar, S., Tripathi, G., & McTernan, P. G. (2018). Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids. Diabetologia, 61, 1155-1166. https://doi.org/10.1007/s00125-018-4558-6 CR - Kawai, T., Autieri M. V., & Scalia, R. (2020). Adipose tissue ın-flammation and metabolic dysfunction in obesity. American Journal of Physiology, 3(320), C375-C391. https://doi.org/10.1152/ajpcell.00379.2020. CR - Kiss, A. L. (2022). Inflammation in focus: The beginning and the end. Budapeşte. Pathology & Oncology Research, 4(27). https://doi.org/10.3389/pore.2021.1610136 CR - Koçak, B., & Öney, B. (2021). Obezitenin inflamasyon ile ilişkisi. Sağlık ve Yaşam Bilimleri Dergisi, 3(3), 174-177. https://doi.org/10.33308/2687248X.202133226 CR - Kojta, I., Chacińska, M., & Błachnio-Zabielska, A. (2020). Obesi-ty, bioactive lipids, and adipose tissue inflammation in in-sulin resistance. Nutrients, 12(1305). https://doi.org/10.3390/nu12051305 CR - Kumar, S., & Kaufman, T. (2018). Childhood obesity. Panminev-ra Medica, 60(4), 200-212. https://doi.org/10.23736/S0031-0808.18.03557-7 CR - Kurniawan, L. B., Rampo, H., Soraya, G. V., Adnan, E., Esa, T., & Widaningsih, Y. (2021). Effect of obesity, glucose control, lipid profiles, and blood pressure on Lp-PLA2 levels in type 2 diabetes mellitus patients. Obesity Medicine, 22(4). https:/doi.org./ 10.1016/j.obmed.2021.100318 CR - Lee, J. (2021). Influences of exercise interventions on over-weight and obesity in children and adolescents. Public Health Nursing, 38(3), 502-516. https://doi.org/10.1111/phn.12862 Magkos, F., Fraterrigo, G., Yoshino, J., Luecking, C., Kirbach, K., Kelley, S. C., de Las Fuentes, L., He, S., Okunade, A. L., Patterson, B. W., & Klein, S. (2016). Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. Cell Metabolism, 23(4), 591-601. https://doi.org/10.1016/j.cmet.2016.02.005 CR - Mehrzad, R. (2023). Introduction to obesity and inflammation (1nd edition). Inflammation and obesity. https://doi.org/10.1016/B978-0-323-90960-0.00007-2 CR - Obradovic, M., Sudar-Milanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A. J., Gojobori, T., & Isenovic, E. R. (2021). Leptin and obesity: Role and clinical implication. Frontiers in Endocrinology, 12. https://doi.org/10.3389/fendo.2021.585887 CR - Özbayer, C., Yağcı, E., & Kurt, H. (2018). Obezite, tip 2 diyabet ve insülin direnci arasındaki bağlantı: İnflamasyon. Tıp Fakültesi Klinikleri, 1(2), 27-36. CR - Parikh, R., Tarıq, S. M., Marinac, C. R., & Shah, U. A. (2022). A comprehensive review of the impact of obesity on plasma cell disorders. Leukemia, 36(2), 301-314. https://doi.org/10.1038/s41375-021-01443-8 CR - Rana, M. N., & Neeland, I. J. (2022). Adipose tissue inflamma-tion and cardiovasacular disease: An update. Current Dia-betes Reports, 22(1), 27-37. https://doi.org/10.1007/s11892-021-01446-9 CR - Roche, H. M. (2019). Dietary modulation of energy homoeosta-sis and metabolic-inflammation. The Proceedings of the Nutrition Society, 78(3), 313-318. https://doi.org/10.1017/S0029665118002872 CR - Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022). Inflammation in obesity, diabetes, and related disorders. Immunity, 55(1), 31-55. https://doi.org/10.1016/j.immuni.2021.12.013 CR - Rubio-Tomás, T., Rueda-Robles, A., Plaza-Díaz, J., & Álvarez-Mercadoc, A. (2022). Nutrition and cellular senescence in obesity-related disorders. Journal of Nutritional Biochemis-try, 99. https://doi.org/10.1016/j.jnutbio.2021.108861 CR - Sleigh, B. C., & Manna, B. (2022). Lymphedema. StatPearls. https://europepmc.org/article/nbk/nbk537239 Stranahan, A. M. (2022). Visceral adiposity, inflammation, and hippocampal function in obesity. Neuropharmacology, 205. https://doi.org/10.1016/j.neuropharm.2021.108920 CR - Şahin, T. & Tozcu, D. (2022). Leptin, mikrobiyota ve obezite ilişkisi. Türkiye Diyabet ve Obezite Dergisi, 6(1), 77-84. https://doi.org/10.25048/tudod.1005455 CR - Tzotzas, T., Flippatos, T.D., Triantos, A., Brucket, E., Tselepis, A. D. & Kiortsis, D. N. (2008). Effects of a low-calorie diet associated with weight loss on lipoprotein-associated phospholipase A2 (Lp- PLA2) activity in healthy obese women. Nutrition, Metabolism and Cardiovascular Diseases, 18(7), 477-482. https://doi.org/10.1016/j.numecd.2007.04.004 CR - Wedell-Neegaard, A., Lehrskov, L.L., Christensen, R. H., Le-gaard, G. E., Dorph, E., Larsen, M. K., Launbo, N., Fagerlind, S. R., Seide, S. K., Nymand, S., Ball, M., Vinum, N., Dahl, C. N., Henneberg, M., Ried-Larsen, M., Nybing, J. D., Christensen, R., Rosenmeier, J. B., Karstoft, K., …Krogh-Madsen, R. (2019). Exercise-induced changes in visceral adipose tissue massa re regulated by IL-6 signal-ing: A rondomized controlled trial. Cell Metabolism, 29(4), 844-855. https://doi.org/10.1016/j.cmet.2018 World Health Organization. (2023, Nisan). Obesity definition. https://www.who.int/health-topics/obesity#tab=tab_1 CR - Wu, H., & Ballantyne,C. M. (2020). Metabolic inflammation and insulin resistance in obesity. Texas. https://doi.org/10.1161/CIRCRESAHA.119.315896 Yan, J., & Horng, T. (2020). Lipid metabolism in regulation of macrophage functions. Trends in Cell Biology, 11-22. https://doi.org/10.1016/j.tcb.2020.09.006 CR - Ying, W., Lee, Y. S., Dong, Y., Seidman, J. S., Yang, M., Isaac, R., Seo, J. B., Yang, B., Wollam, J., Riopel M., McNelis J., Glass C. K., Olefsky, J. M. & Fu, W. (2019). Expansion of is-let-resident macrophages leads to inflammation affecting β cell proliferation and function in obesity. Cell Metabolism, 29(2), 457-474. https://doi.org/10.1016/j.cmet.2018.12.003 CR - Yousefirad, N. (2020). Yüksek protein diyeti alan sıçanlarda antioksidan ve inflamasyon biyobelirteçleri ile obezite gelişimi arasındaki ilişkinin nesillere bağlı değişiminin incelenmesi. [Doktora Tezi]. İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü. UR - https://dergipark.org.tr/en/pub/erusaglik/issue//1216604 L1 - https://dergipark.org.tr/en/download/article-file/2821291 ER -