@article{article_1217177, title={Investigation of the biocompatibility and in vivo wound healing effect of Cotinus coggygria extracts}, journal={Ankara Üniversitesi Veteriner Fakültesi Dergisi}, volume={71}, pages={269–280}, year={2024}, DOI={10.33988/auvfd.1217177}, author={Bozkaya, Esra and Türk, Mustafa and Ekici, Hüsamettin and Karahan, Siyami}, keywords={cytotoxicity, Cotinus coggyria, genotoxicity, hemolysis, In vivo wound healing}, abstract={Cotinus coggygria is widely recognized its antiseptic, anti-inflammatory, antimicrobial, antihemorrhagic, and wound-healing properties. In this, aimed to evaluate the phenolic contents, cytotoxicity/proliferation, hemolytic, antimicrobial, genotoxic, apoptotic, necrotic activities, and in vivo wound healing effects of C. coggygria, a plant species known to have beneficial effects on wound healing. TOF-LC/MS analyzes revealed that the methanol extract of C. coggygria leaves contained flavonoids and phenolic compounds such as gallic acid (18.5 mg/kg), catechin (4.6 mg/kg), protocatesic acid (0.6 mg/kg), vanillic acid (8.4 mg/kg), ellagic acid (0.1 mg/kg), rosmarinic acid (0.1 mg/kg), quercetin (15 ppb) and C. coggygria stems contained such as gallic acid (24.6 mg/kg), catechin (155.1 mg/kg), chlorogenic acid (1.9 mg/kg), 4-hydroxybenzoic acid (383.3 mg/kg), rutin (2.5 mg/kg), ellagic acid (15.1 mg/kg), apigenin 7-glycoside (10.5 mg/kg), rosmarinic acid (0,4 mg/kg), quercetin (15.2 mg/kg), naringenin (279.1 mg/kg). Consequently, C. coggyria has a positive effect on wound healing with antibacterial properties, particularly against E. coli, and without cytotoxic, genotoxic, or hemolytic effects at test concentrations. In the in vivo burn model, wounds treated with leaf and stem extracts healed faster than the control group. Thus, C. coggygria is an effective plant for wound healing with antibacterial properties, particularly against E. coli, and without cytotoxic, genotoxic, and hemolytic effects.}, number={3}, publisher={Ankara University}, organization={This study was financially supported by the Ministry of Science, Industry and Technology SANTEZ Project No. 0352.STZ.2013-2 of the Ministry of Science, Industry and Technology.}