TY  - JOUR
T1  - EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL IN ADULTS Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü Üzerine Etkisi
AU  - Çıftçı Küsbecı, Tuba
AU  - Argun Barış, Serap
AU  - Yıldız, Füsun
AU  - Baştığıt, İlknur
AU  - Boyacı, Haşim
AU  - Ilgaz, Ahmet
PY  - 2022
DA  - December
DO  - 10.16919/bozoktip.1133710
JF  - Bozok Tıp Dergisi
PB  - Yozgat Bozok University
WT  - DergiPark
SN  - 2146-4006
SP  - 111
EP  - 119
VL  - 12
IS  - 4
LA  - tr
AB  - ABSTRACTObjective: The aim of this study is to evaluate the effects of serum vitamin D level and body mass index(BMI) on asthma control and pulmonary functions in asthmatic patients.Material and Methods: Thirty-five healthy normal controls and 60 patients with asthma were included inthe study between December 2016 and February 2017. At initial admission, demographic characteristicsand pulmonary function tests (PFT) were recorded and laboratory tests including serum vitamin D, calcium,phosphorus, parathormone and alkaline phosphatase levels were measured. Asthma control test (ACT) wasperformed to asthmatic patients. Fifty-three patients with asthma and 32 healthy controls with decreasedvitamin D level were consulted with Endocrinology Department for vitamin D replacement therapy. ACT andPFT were repeated after therapy at third month in asthmatic patients.Results: There were totally 95 individuals; 76 females (80%) and 19 males (20%), There were no significantdifference between age, gender and demographic characteristics between asthmatics and controlgroup. Smoking status and passive smoking rates were similar. There was no significant difference betweendaily sun exposure, calcium containing diet and menopausal status. Serum phosphorus, calcium, alkalinephosphatase, parathormone and 25-hydroxyvitamin D levels were similar in both groups. Vitamin levelswere low in about 90% of both groups. On the first admission, 71.7% of asthmatic patients were uncontrolled,while the rate of uncontrolled patients decreased to 13.2% after the post-replacement evaluation.There was a significant increase of ACT with respect to vitamin D replacement therapy (22.4 ± 2.7 vs 16 ±5.4, p=0.001). The mean BMI were high in both groups (≥30 kg/m²). The mean ACT score was lower in obeseasthmatics than in non-obese patients, but the difference was not significant (15.3 ± 5.4 vs. 17.5 ± 4.8, p=0.1). Presence of controlled or uncontrolled disease was similar between the obese and non-obese groups(p = 0.744).Conclusion: It is suggested that vitamin D replacement therapy had positive effects on asthma control andpulmonary functions but further multicenter, prospective studies with large number of cases are needed toevaluate the effect of vitamin D replacement therapy on these parameters.Keywords: Asthma; Vitamin D; Asthma Control Test (ACT); Pulmonary Function Test (PFT)
KW  - EFFECT OF VITAMIN D LEVELS ON ASTHMA CONTROL IN
ADULTS
KW  - Astımlı
KW  - Astımlı Hastalarda D Vitamini Düzeyinin Astım Kontrolü Üzerine
Etkisi
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UR  - https://doi.org/10.16919/bozoktip.1133710
L1  - https://dergipark.org.tr/en/download/article-file/2833943
ER  -