TY  - JOUR
T1  - Models of experimental epilepsy
TT  - Models of experimental epilepsy
AU  - Bambal, Gönül
AU  - Çakıl, Duygu
AU  - Ekici, Fatih
PY  - 2011
DA  - March
DO  - 10.5799/ahinjs.01.2011.01.0224
JF  - Journal of Clinical and Experimental Investigations
JO  - J Clin Exp Invest
PB  - Aydın ECE
WT  - DergiPark
SN  - 1309-8578
SP  - 118
EP  - 123
VL  - 2
IS  - 1
LA  - tr
AB  - Epilepsi, % 1 prevelansa sahip olduğu tahmin edilen, dünyada en yaygın görülen ciddi nörololojik durumdur. Birçok sayıda, deneysel epilepsi ve nöbet modeli geliştirilmiştir. Bu deneysel modeller hayvanlarda elektrik uyarımı, kimyasal konvülsanlar, genetik modeller, yapısal lezyonlar, fiziksel uyaranlar (soğuk, basınç, hipertermi, elektriksel) ile oluşturulmaktadır. İyi karakterize edilmiş hayvan modelleri epileptogenezisin (normal nöronal bir ağın spontan, hipereksitabilite ağına değişmesi) altında yatan temel mekanizmaların anlaşılmasına olanak sağlayabilmektedir. Üstelik bu modeller epilepsi tedavisinde yeni tedavi edici yaklaşımların belirlenmesinde de yararlı olabilmektedir. Klin Den Ar Derg 2011; 2(1): 118-123
KW  - Epilepsi
KW  - nöbet
KW  - deneysel modeller
N2  - Epilepsy is the most common serious neurological condition in the world, with an estimated prevalence of 1% of the population. A large number of experimental models of seizure and epilepsy have been developed. These experimental models are elicited by chemical convulsants, electrical stimulation, genetic models, structural lesions, physical stimuli (cold, pressure, hyperthermia, electrical) in animals. Well-characterized animal models may allow the understanding of the basic mechanisms underlying epileptogenesis (it refers to the alteration of a normal neuronal network into a hyperexcitable network in which recurrent, spontaneous seizures occur). Moreover, these models might also prove useful in identifying novel therapeutic approaches to treatment of epilepsy.
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UR  - https://doi.org/10.5799/ahinjs.01.2011.01.0224
L1  - https://dergipark.org.tr/en/download/article-file/104416
ER  -