@article{article_1232446, title={Pentoxifylline and Tocopherol in the Management of Stage III Medication-Related Osteonecrosis of the Jaw: A Case Report}, journal={Akdeniz Diş Hekimliği Dergisi}, volume={2}, pages={162–167}, year={2023}, author={Merey, Selen Elif and Demiray, Mehmet and Özalp, Öznur and Sindel, Alper and Altay, Mehmet Ali}, keywords={MRONJ, pathologic fracture, PENTO, pentoxifylline, tocopherol}, abstract={Regimen of pentoxifylline and tocopherol (PENTO) has been widely recommended in prevention and treatment of osteoradionecrosis, however, limited data has been found regarding the efficacy of this protocol in management of MRONJ. This report aims to present the outcomes of PENTO protocol in a stage III MRONJ case with pathologic mandible fracture who was not convenient for surgery. A 68-year-old male patient with prostate cancer and a three-year history of intravenous zoledronic acid was referred to our clinic for impaired healing of extraction site in mandible in 2018. He was non-cooperated for follow-up and control appointments and two years later from the first visit, it was observed that a pathologic fracture occured in the region. Due to the ongoing chemotherapy of the patient, PENTO protocol was initiated. At the end of a seven-month period, spontaneous sequestration, healing of the fracture and healing of the mucosa was observed. Findings of the presented case and current literature suggest that PENTO protocol may be a promising treatment modality in MRONJ management. However, further clinical and experimental research involving larger sample size is necessary to clarify the role of this regimen in the treatment of MRONJ.}, number={3}, publisher={Akdeniz University}