@article{article_1245929, title={Do Alterations In Serum Leptin, Adiponectin, Resistin, C Peptide, Il-10, Il-22 And Visfatin Levels Have An Impact On Survival In Patients With Advanced Stage Gastric And Colon Cancer?}, journal={Journal of Contemporary Medicine}, volume={13}, pages={451–458}, year={2023}, author={Özlü, Can and Gokoz Dogu, Gamze and Kargı, Ayşegül and Akça, Hakan and Demiray, Aydın and Yapar Taşköylü, Burcu and Demiray, Atike Gökçen and Değirmencioğlu, Serkan and Yaren, Arzu and Ergin, Ahmet}, keywords={Cancer cachexia, Adipocytokines, Adiponectin, Gastric cancer, Colon cancer}, abstract={Abstract Background/Aims: Pathogenesis of cancer cachexia is not fully understood yet; however, adipocytokines are considered necessary in this context. In this study, leptin, adiponectin, resistin, c-peptid, IL-10, IL-22, visfatin which are considered to be among markers of cancer cachexia were assessed. Methods: Fifty-three patients (34 male, 19 female) and 20 healthy people as a control group were included into this study. Blood samples were stored in deep freeze at -70 ºC and all of the samples were analyzed with appropriate biochemistry kit. Along with demographic data and laboratory tests results serum adiponectin, leptin, IL-10, IL-22, C peptide, resistin, visfatin levels were measured in 3 different time period both in patient and control group. Statistical data were evaluated by SPSS v22. Results: There was no statistically significant relationship between adipocytokine levels and progression-free survival. Higher resistin and IL-10 levels were associated with shorter overall survival (p=0.035, p=0.14, respectively). There was no significant relationship between other cytokines and overall survival. Multivariate analysis has shown that higher serum Ca 19.9 levels (OR 0.226, P=0.005), lower BMI (OR 5.726, p= 0.007), higher serum IL-10 levels (OR 0.329, p= 0.042) were factors showing an impact on progression-free survival; lower serum albumin levels (OR 0.282, p=0.013), higher serum LDH levels (OR 0,338, p=0.012), low BMI at diagnosis (OR 5.19, P <0.0005) were factors having an impact on overall survival. Conclusions: Our study detected an association between resistin, adipocytokine, and IL10 level and overall survival.}, number={3}, publisher={Rabia YILMAZ}, organization={Pamukkale Üniversitesi}