@article{article_124924, title={Abnormal P50 Suppression in Migraine Patients during the Attack and Interattack Period}, journal={The Journal of Kırıkkale University Faculty of Medicine}, volume={17}, pages={7–13}, year={2016}, DOI={10.24938/kutfd.124924}, url={https://izlik.org/JA65DJ88MG}, author={Kamışlı, Suat and Tecellioğlu, Mehmet and Kahraman, Handan}, keywords={Sensory gating,pedinculopontine nucleus,cholinergic insufficiency,migraine}, abstract={<p>Habituation can be defined as an adaptive mechanism that protects the cortex against sensory overload in normal persons. The most common interictal electrophysiological abnormality in <br />migraine is lack of habituation. İnterestingly, habituation is normalized just before and during a migraine attack. It was aimed to provide another perspective on habituation response <br />through P50 suppression (sensory gating) method, used in the evaluation of the pre- attention habituation response, under the cholinergic control. The study population consisted of 17 migraine patients without aura and 18 healthy volunteers were included as a control group. The method for demonstrating sensory gating is the pairedstimulus P50 paradigm. We compared the initial stimulus (S1), second stimulus (S2) amplitude and latency and the percentage of sensory gating in the ictal and interictal periods with healthy controls. The percentage of P50 suppression of the migraine group in the attack and interictal periods were significantly reduced compared with those of the control group (P < 0.05). This difference was related to significantly lower S1 amplitude in the migraine group compared with the control group (P < 0.05). Although, the S1 and S2 amplitudes and percentages of P50 suppression were closer to the control values during an attack, the differentiations between groups was observed still significant (P < 0.05). This conclusion supports the notions of loss of habituation associated with interictal cortical hypoexcitability and the ictal normalization of the loss of habituation. The present study suggests that migraine patients may have a dysfunction in thalamo-cortical excitatory cholinergic activity <br /> </p>}, number={3}