TY  - JOUR
T1  - Increased Expression of the Actin-Related Protein 2 (ACTR2) Gene in Pterygium
AU  - Şahin, Kübra
AU  - Abdullah, Soran
AU  - Ateş, Ömer
AU  - Bozkurt, Nihan
AU  - Savkin, Sadegul Tuncer
AU  - Deniz Demir, Helin
AU  - Tetikçok, Ramazan
PY  - 2024
DA  - September
DO  - 10.33808/clinexphealthsci.1254942
JF  - Clinical and Experimental Health Sciences
PB  - Marmara University
WT  - DergiPark
SN  - 2459-1459
SP  - 631
EP  - 635
VL  - 14
IS  - 3
LA  - en
AB  - Objective: Pterygium is a fibrovascular conjunctival degeneration whose pathogenesis remains unclear, although many risk factors have been identified. In our study, we purposed to find the level of Actin Related Protein 2 (ACTR2) gene expression in healthy conjunctiva tissues and pterygium to increase our understanding of the pathogenesis of pterygium.Methods: The study included 27 patients who underwent pterygium excision. ACTR2 mRNA expression level in healthy conjunctiva tissues and pterygium were determined by the Real-Time PCR method.Results: According to the results we obtained, ACTR2 gene expression was increased in 74% (20/27) of our cases, while ACTR2 gene expression was decreased in 26% (7/27). ACTR2 mRNA expression was detected to be remarkably higher in pterygium in proportion to conjunctiva tissue (p
KW  - Actin cytoskeleton
KW  - ACTR2
KW  - Cell migration
KW  - Expression
KW  - Pterygium
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UR  - https://doi.org/10.33808/clinexphealthsci.1254942
L1  - https://dergipark.org.tr/en/download/article-file/2968079
ER  -