TY  - JOUR
T1  - Effects of the Aronia Melanocarpa extract action on the activity of mitochondrial creatine kinase under immobilization stress in old rats
TT  - Effects of the Aronia Melanocarpa extract action on the activity of mitochondrial creatine kinase under immobilization stress in old rats
AU  - Shvets, Volodymyr
AU  - Maslak, Hanna
AU  - Davydov, Vadim
AU  - Berest, Halyna
AU  - Nosulenko, Inna
AU  - Voskoboinik, Oleksii
AU  - Omelianchyk, Liudmyla
AU  - Brazhko, Oleksandr
PY  - 2023
DA  - December
Y2  - 2023
DO  - 10.52794/hujpharm.1269999
JF  - Hacettepe University Journal of the Faculty of Pharmacy
JO  - HUJPHARM
PB  - Hacettepe University
WT  - DergiPark
SN  - 2458-8806
SP  - 333
EP  - 339
VL  - 43
IS  - 4
LA  - en
AB  - The effects of the Aronia melanocarpa extract on mitochondrial creatine kinase isoenzyme of the old rats heart under stress were studied. The research was performed on 30 male rats of the Wistar line. For expiriment were used old (22–25 months) animals. It was established, that the injection of the extract (Aronia melanocarpa) at a dose of 0.2 g/kg 60 minutes before the immobilization has limited sensitivity of the heart muscle’s CPK-MT to damaging stress factors (reduced medium pH, increased medium tonicity, increased concentration of calcium, activated free radical processes), and helps the normalization of its kinetic properties, has an influence on the myocardium’s kinetic supply. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.
KW  - stress
KW  - myocardium
KW  - aging
KW  - Aronia melanocarpa extract
KW  - mitochondrial creatine kinase.
N2  - The effects of the Aronia melanocarpa extract on mitochondrial creatine kinase isoenzyme of the old rats heart under stress were studied. The research was performed on 30 male rats of the Wistar line. For expiriment were used old (22–25 months) animals. It was established, that the injection of the extract (Aronia melanocarpa) at a dose of 0.2 g/kg 60 minutes before the immobilization has limited sensitivity of the heart muscle’s CPK-MT to damaging stress factors (reduced medium pH, increased medium tonicity, increased concentration of calcium, activated free radical processes), and helps the normalization of its kinetic properties, has an influence on the myocardium’s kinetic supply. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.
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UR  - https://doi.org/10.52794/hujpharm.1269999
L1  - https://dergipark.org.tr/en/download/article-file/3031460
ER  -