TY  - JOUR
T1  - Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease
TT  - İnterferon-gamma ile İndüklenebilir Protein-10: COVID-19 Hastalığı için Bir  Ölüm Göstergesi Değildir
AU  - İslam, Mahmud
AU  - Dheir, Hamad
AU  - Özözen Şahin, Elif
AU  - Yaylacı, Selcuk
AU  - Aydın, Abdülkadir
AU  - Pınar, Musa
AU  - Güçlü, Ertuğrul
AU  - Genç, Ahmed Cihad
AU  - Köroğlu, Mehmet
AU  - Karabay, Oğuz
PY  - 2023
DA  - September
Y2  - 2023
DO  - 10.26453/otjhs.1276809
JF  - Online Turkish Journal of Health Sciences
JO  - OTSBD
PB  - Oğuz KARABAY
WT  - DergiPark
SN  - 2459-1467
SP  - 363
EP  - 368
VL  - 8
IS  - 3
LA  - en
AB  - Objective: Interferon-gamma inducible protein-10 (IP-10) released from macrophages is associated with thrombosis. We aimed to investigate patients' biochemical markers following severe COVID-19, concentrating on the role of IP-10 in mortality.  Materials and Methods: In our study, we retrospectively evaluated data from 88 (females, 44.3%) severe patients followed in our university hospital's intensive care unit (ICU). We obtained demographic and laboratory data from our study population's files and electronic records, including D-dimer, ferritin, uric acid, IP-10 values, and other biochemical markers.     Results: The mean age of all 88 patients with COVID-19 infection followed in the ICU was 70.5 ±10 years. The median for lymphocyte count was 1.3 (1-2.1) vs 0.8 (0.5-1.1) K/uL, ferritin 151 (90.7-255) vs 624 (296-1254) mcg/L, D-dimer 386 (293.5-650) vs 1280 (871-2245) ug/L, LDH 220 (185-286) vs 429.5 (368-560) U/L with a p-value of
KW  - Biomarker
KW  - COVID-19
KW  - IP-10
KW  - mortality
N2  - Amaç: Makrofajlardan salınan interferon-gama indüklenebilir protein-10 (IP-10) tromboz ile ilişkilidir. Bu çalışma, şiddetli COVID-19 nedeniyle takip edilen hastaların biyokimyasal belirteçlerini ve IP-10'un mortaliteyi göstermedeki rolünü araştırmayı amaçladı. Materyal ve Metot: Bu çalışmada üniversite hastanesinin yoğun bakım ünitesinde (YBÜ) takip edilen 88 (Kadın %44,3) ağır hastanın retrospektif verileri değerlendirildi. Demografik ve laboratuvar verileri ile D-dimer, Ferritin, Ürik asit, IP-10 değerleri ve diğer biyokimyasal belirteçlere ilişkin veriler ölen ve yaşayan hastaların dosyalarından elde edildi. Bulgular: Yoğun bakımda takip edilen COVID-19 enfeksiyonlu 88 hastanın yaş ortalaması 70,5 ±10 idi. Hayatta kalan gurupta, lenfosit sayısı 1,3 (1-2,1) K/uL, ferritin 151 (90,7-255), D-dimer 386 (293,5-650), LDH 220 (185-286) iken, ölen hastalarda ise, lenfosit sayısı 0,8 (0,5-1,1), ferritin 624 (296-1254) mcg/L, D-dimer 1280 (871-2245) ug/L, LDH 429.5 (368-560) U/L  saptandı. Bu parametrelerde p değeri
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UR  - https://doi.org/10.26453/otjhs.1276809
L1  - https://dergipark.org.tr/en/download/article-file/3058593
ER  -