@article{article_1292019, title={The clinical and reproductive outcomes of endometrial intraepithelial neoplasia: experience of 117 cases}, journal={Türk Jinekolojik Onkoloji Dergisi}, volume={23}, pages={52–57}, year={2023}, DOI={10.59215/trsgo.1292019}, author={Giray, Burak and Dönmez, Emin Erhan and Kaya, Fatih and Sözen, Hamdullah and Salihoglu, Yavuz and Topuz, Samet and Vatansever, Doğan}, keywords={Endometrial Hyperplasia, Endometrial Intraepithelial Neoplasia, Endometrial Cancer, Fertility-Sparing Treatment}, abstract={Aim: Hysterectomy is the suggested treatment for endometrial intraepithelial neoplasia since there is a high risk of coexisting endometrial adenocarcinoma in this subset of patients. However, fertility sparing treatment modalities can also be an option for patients with endometrial intraepithelial neoplasia who desire to preserve their fertility. In this study our aim was to evaluate the clinical and reproductive outcomes of endometrial intraepithelial neoplasia. Materials and methods: We retrospectively analyzed the records of 117 patients with atypical hyperplasia (AH)/endometrial intraepithelial neoplasia (EIN) in a tertiary gynecological cancer center. The median follow-up time was 54 (7-96) months. Results: One hundred and one women underwent hysterectomy. The rate of coexistent endometrial carcinoma in women with AH/EIN was 33.7%. Sixteen women were treated conservatively. The complete response rate was 75% in patients after a treatment period of 12 months. Four of the patients in the infertile group had a successful live birth, 2 spontaneously and 2 with in vitro fertilization. Two patients in the fertile group had a successful live birth, 2 spontaneously. Conclusion: Fertility sparing management is a feasible option for patients with atypical hyperplasia. However, it is crucial that there are high rates of coexisting endometrial cancer in these patients. Patients with AH/EIN should be followed up carefully for endometrial adenocarcinoma with regular endometrial samplings.}, number={3}, publisher={Türk Jinekolojik Onkoloji Derneği}