@article{article_1302701, title={Effects of Bromelain on Oxidative Stress and Lung Tissue Histopathology in an Experimental Rat Sepsis Model}, journal={Kocatepe Veterinary Journal}, volume={16}, pages={252–259}, year={2023}, DOI={10.30607/kvj.1302701}, author={Akaras, Nurhan and Toktay, Erdem and Şimşek, Hasan and Aydemir Celep, Nevra and Yüce, Neslihan}, keywords={Lung, Bromelain, Sepsis, Inflammation, Oxidative Stress}, abstract={Sepsis is an inflammatory syndrome that targets the lung tissue. Bromelain (BRO) is an enzyme complex known for its anti-inflammatory properties. In this study, the protective effect of BRO on lung injury due to sepsis induced by cecal ligation and puncture (CLP) in Sprague-Dawley rats was investigated by biochemical and histopathological methods. Forty Sprague dawley rats were randomly divided into five groups as control, CLP, BRO, CLP+BRO 50 and CLP+BRO 100. In the study, after oral administration of 50 and 100 mg/kg BRO (total of 7 applications for 7 days) to rats, laparotomy and CLP were performed. The data showed that due to its antioxidant properties, BRO decreased CLP-induced myeloperoxidase (MPO) and lipid peroxidation (MDA) (p <0,001), increased glutathione (GSH) levels, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities (p <0,001). Additionally, CLP-induced lung histological changes were reduced with BRO supplementation. The results showed that BRO treatment has an antioxidant, anti-inflammatory effect on CLP-induced lung toxicity and helps preserve lung tissue architecture owing to its regulatory effect.}, number={3}, publisher={Afyon Kocatepe University}