TY  - JOUR
T1  - Exopolysaccharide from Rhodococcus pyridinivorans ZZ47 Strain: Evaluation of Biological Activity and Toxicity
AU  - Ceyhan Güvensen, Nur
AU  - Taşkaya, Aylin
AU  - Güler, Cem
AU  - Şancı, Ebru
AU  - Karabay, Ülkü
PY  - 2023
DA  - June
DO  - 10.56430/japro.1307611
JF  - Journal of Agricultural Production
JO  - J Agri Pro
PB  - Gökhan ARSLAN
WT  - DergiPark
SN  - 2757-6620
SP  - 63
EP  - 71
VL  - 4
IS  - 1
LA  - en
AB  - Microbial polysaccharides are extracellular polymeric macromolecules excreted in microorganisms. These are widely used in food, cosmetic and pharmaceutical industries. One of them, exopolysaccharides (EPS), plays important role against the factors such as phage attack, antibiotics, toxic compounds or osmotic stress. Recently, this natural polymer has received great attention due to their therapeutic potential. The purpose of the study was to evaluate biological activity and potential toxicity of EPS from Rhodococcus pyridinivorans ZZ47 strain isolated from nature. EPS has no genotoxic effect on Salmonella typhimurium TA98, TA102, and TA1537 strains by Ames Test. No death occurred with single dose oral toxicity test of EPS and LD50 value of it is calculated by >2000 mg/kg in mice. The EPS showed antibiofilm activity on different bacteria. In addition, EPS demonstrated dose-dependent anti-angiogenic properties by HET-CAM test. In conclusion, the isolated EPS has antioxidant activity with no genotoxicity and the biological activities of the polymer indicated that it may be suitable for use in different sectors and industrial applications.
KW  - Acute toxicity
KW  - Anti-angiogenic activity
KW  - Antibiofilm activity
KW  - Exopolysaccharide
KW  - Genotoxicity
KW  - Rhodococcus pyridinivorans
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UR  - https://doi.org/10.56430/japro.1307611
L1  - https://dergipark.org.tr/en/download/article-file/3179201
ER  -