TY  - JOUR
T1  - THE ROLE OF PET CT IN CANCER OF UNKNOWN PRIMARY Primeri Bilinmeyen Kanserlerde PET BT'nin Rolü
AU  - Kandemır, Ozan
AU  - Kandemir, Fadime
PY  - 2023
DA  - June
DO  - 10.16919/bozoktip.1117413
JF  - Bozok Tıp Dergisi
PB  - Yozgat Bozok University
WT  - DergiPark
SN  - 2146-4006
SP  - 8
EP  - 13
VL  - 13
IS  - 2
LA  - tr
AB  - ABSTRACTObjective: This study aimed to investigate the diagnostic value of positron emission tomography/computedtomography (PET/CT) in detecting the primary focus and in suspicious foci in patients who underwent PET/CT with a pre-diagnosis of carcinoma of unknown primary.Material and Methods: In this retrospective study, a total of 49 patients who underwent PET/CT scan witha prediagnosis of carcinoma of the unknown primary between 2015 and 2019, and whose clinical follow-upand histopathological data were available, were included. PET/CT study was performed in 20 (40%) patientsafter the metastatic lesion was detected as a result of pathology, and in 29 (60%) patients due to clinicalfindings and imaging methods and suspicion of malignancy. The histopathological and clinical evaluation ofthe patients before PET/CT and the primary surgery, histopathological examinations and clinical follow-upsafter PET/CT were examined. The success of PET/CT in detecting primary lesions and evaluating suspiciouslesions in metastatic cases was analyzed.Results: Seventeen (34.7%) of the patients were female and 32 (65.3%) were male. A primary malignanttumor was detected in 34 (85%) of 40 patients with PET/CT. Regional distribution in patients with primarycancer focus; 9 pancreases, 9 lungs, 4 livers, 3 urothelial, 2 thyroids, 1 vertebra, 1 breast, 1 ovary, 1 esophagus,1 prostate, 1 iliac bone, 1 skin, 1 stomach and 1 colon. In the follow-up of 6 cases whose primary couldnot be determined; Cervical cancer was detected in 1, ovarian cancer in 1, and the primary focus could notbe detected in the clinical follow-up of 4 metastatic patients.Conclusion: PET/CT is highly successful in detecting cancers whose primary is unknown. Therefore, PET/CT isa diagnostic imaging method for the detection of the primary in cancer patients whose primary is unknown.
KW  - THE ROLE OF PET CT IN CANCER OF UNKNOWN
KW  - PRIMARY
KW  - Primeri Bilinmeyen Kanserlerde PET BT
CR  - 1. Rassy E, Assi T, Pavlidis N. Exploring the biological hallmarks of cancer of unknown primary: where do we stand today? Br J Cancer. 2020;122(8):1124–32.
CR  - 2. Dermawan JK, Rubin BP. The role of molecular profiling in the diagnosis and management of metastatic undifferentiated cancer of unknown primary: Molecular profiling of metastatic cancer of unknown primary. Semin Diagn Pathol. 2021;38(6):193-8.
CR  - 3. Siegel RL, Miller KD, Jemal A. Cancer statistics. CA. Cancer J Clin. 2019;69(1):7-34.
CR  - 4. Nissan E, Amit U, Baron L, Zabatani A, Urban D, Barshack I, et al. The usefulness of [18F]FDG PET/ CT in detecting and managing cancers with unknown primary site depends on histological subtype. Sci Rep. 2021;11(1):17732.
CR  - 5. Soni N, Ora M, Aher PY, Mishra P, Maheshwarappa RP, Priya S, et al. Role of FDG PET/CT for detection of primary tumor in patients with extracervical metastases from carcinoma of unknown primary. Clin Imaging. 2021;78:262-70.
CR  - 6. Woo S, Becker AS, Do RKG, Schoder H, Hricak H, Vargas HA. Impact of 18F-Fluorodeoxyglucose positron emission tomography on management of cancer of unknown primary: systematic review and meta-analysis. Eur J Cancer. 2021;159:60-77.
CR  - 7. Stares M, Purshouse K, Knowles G, Haigh R, Irvine J, Gatenby A, et al. Characterisation and outcomes of patients referred to a regional cancer of unknown primary team: a 10-year analysis. Br J Cancer. 2021;125(11):1503-10
CR  - 8. Fizazi K, Greco FA, Pavlidis N, Daugaard G, Oien K, Pentheroudakis G, et al. Cancers of unknown primary site: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol.2015;26 Suppl 5:v133–8.
CR  - 9. Pavlidis N, Fizazi K. Carcinoma of unknown primary (CUP). Crit Rev Oncol Hematol. 2009;69(3):271-8.
CR  - 10. Kwee TC, Basu S, Cheng, Alavi A. FDG PET/CT in carcinoma of unknown primary. Eur J Nucl Med Mol Imaging. 2010;37(3):635-44.
UR  - https://doi.org/10.16919/bozoktip.1117413
L1  - https://dergipark.org.tr/en/download/article-file/3213000
ER  -