@article{article_1317273, title={Gastroprotective Effects of Jujuba (Ziziphus jujuba) Fruit Extract Against the Ethanol-Related Gastric Ulcer in Rats}, journal={Journal of Contemporary Medicine}, volume={13}, pages={1046–1052}, year={2023}, author={Tanyeli, Ayhan and Güler, Mustafa Can and Eraslan, Ersen and Bozhüyük, Mehmet Ramazan and Ekinci Akdemir, Fazile Nur and Toktay, Erdem and Kurt, Nezahat and Özkan, Gülay and Çapanoğlu Güven, Esra}, keywords={Ethanol, gastric ulcer, proinflammatory cytokines, caspase-3, Ziziphus jujuba}, abstract={Abstract Objective: Gastric ulcer is a global health problem. Alcohol consumption and nonsteroidal anti-inflammatory drugs may lead to gastric ulcers. Here, we examined the possible gastroprotective effects of Ziziphus jujuba (Zj) fruit extract on a rat model of ethanol-induced gastric ulcer. Material and Methods: Chemical properties of Zj were specified using performance liquid chromatography coupled to mass spectrometry. The animals were administered Zj extract (4-8 ml/kg) before administering absolute ethanol. Oxidative stress and proinflammatory markers, immunoexpression of NF-ĸB and caspase-3 were measured to evaluate Zj’s effects. Results: Zj fruit extract significantly reduced values of cytokines such as TNF-α, IL-1β, and IL-6 and the expressions of NF-ĸB and caspase-3 in the immunohistologic analysis. We found out ulcerative foci in the ulcer group in the histopathological analysis, while we didn’t observe ulcerative foci in the treatment groups. Conclusion: This experimental study showed that Zj fruit ameliorated the ethanol-induced gastric ulcer model in rats.}, number={6}, publisher={Rabia YILMAZ}