@article{article_1322620, title={Evaluation of the relationship between ETCO2 and delta CO2 pressure and the severity of disease in COVID-19 pneumonia}, journal={Clinical and Experimental Health Sciences}, volume={15}, pages={22–26}, year={2025}, DOI={10.33808/clinexphealthsci.1322620}, author={Altun, Mehmet Emin and Emektar, Emine and Çorbacıoğlu, Şeref Kerem and Çevik, Yunsur}, keywords={COVID-19, ETCO₂, deltaCO₂, ARDS, viral pneumonia}, abstract={Objective: In this study, we aimed to determine end-tidal carbon dioxide (ETCO₂) and deltaCO₂ levels in patients with Coronavirus Disease 2019 (COVID-19) pneumonia and examine the relationship between these two parameters and the severity of disease. Methods: Patients with COVID-19 were included in the study. ETCO₂ values were recorded and deltaCO₂ values were calculated. They were divided into two groups: mild-moderate and severe patients. An analysis was performed to determine the threshold values for ETCO₂ and deltaCO₂ in mild-moderate and severe patient groups. Results: A total of 83 patients were included in our study. Of the patients, 43 (51.8%) patients had mild/moderate disease and 40 (48.2%) had severe disease. The AUC value was 0.910 for ETCO₂ (95% CI; 0.840-0.980, p <0.001) and was 0.927 for DeltaCO₂ (95% CI; 0.864-0.990, p <0.001). To discriminate patients in the severe group, considering a best cut-off value of 22.5 for ETCO₂, the sensitivity and specificity values for this value were 95% and 80%, respectively. Considering a best cut-off value of 11.1 for deltaCO₂, the sensitivity and specificity values for this value were 95% and 77%, respectively. As a result of the DeLong test, the predictive values of deltaCO₂ and ETCO₂ for the severe patient group was found to be better than and similar to PCO2. Conclusion: We showed that low ETCO₂ and high deltaCO₂ values are safe parameters that can be used to predict the severity of disease in patients who apply and are monitored due to COVID-19 pneumonia.}, number={1}, publisher={Marmara University}, organization={yok}