TY  - JOUR
T1  - The potential therapeutic and/or protective effects of steroid, PRP and melatonin on noise-induced hearing loss in rats
AU  - Baklacı, Deniz
PY  - 2023
DA  - March
DO  - 10.5505/achmedj.2023.25744
JF  - ACH Medical Journal
JO  - ACH Med J
PB  - Ankara Şehir Hastanesi
WT  - DergiPark
SN  - 2822-5872
SP  - 36
EP  - 44
VL  - 2
IS  - 2
LA  - en
AB  - Introduction: To investigate the potential therapeutic and protective effects of steroid, platelet-rich plasma (PRP), and melatonin treatment on noise-induced hearing loss (NIHL).Methods: A total of 42 rats were divided into five groups: Group 1 didnot receive any drug, Group 2 received methylprednisolone via the intratympanic route at 24 hours after acoustic trauma (AT), Group 3 received PRP via the intratympanic route at 24 hours after AT, Group 4 received intraperitoneal melatonin at 24 hours before AT, and Group 5received intraperitoneal melatonin at 24 hours after AT. Two of the 42rats were sacrificed and used for blood source material to prepare PRP.Each group was exposed to noise at the 105 dB sound pressure levelfor 12 hours to induce AT. Auditory brainstem responses (ABRs) weredetermined before AT and on days 1 and 28 after AT, and then histomorphological assessment was performed to identify cellular changes.Results: In the ABR test performed on day 28 after AT, a statistically significant improvement was found in the hearing thresholds of all the fourtreatment groups compared to the control group (p < 0.05). The improvement in the melatonin groups (Groups 4 and 5) was statistically significantly better than in the steroid and PRP groups (p < 0.05). Although the hearing thresholds of the steroid group were better than thoseof the PRP group, this difference was not statistically significant (p >0.05). As a result of the histopathological examination performed onday 28 after AT, cell loss after AT was statistically significantly reducedin all the experimental groups compared to the control group (p < 0.05).Conclusion: Based on ABR testing and histopathological findings in a rat model, we conclude that melatonin may be effective in reducing NIHL and noise-induced cochlear damage.
KW  - noise
KW  - acoustic trauma
KW  - hearing loss
KW  - auditory brainstem responses
KW  - melatonin
KW  - platelet-rich plasma
KW  - steroid
UR  - https://doi.org/10.5505/achmedj.2023.25744
L1  - https://dergipark.org.tr/en/download/article-file/3247363
ER  -