TY - JOUR T1 - The Evaluation of Testes by Shear Wave Elastography in Patients with Isolated Hypogonadotropic Hypogonadism TT - İzole hipogonadotropik hipogonadizmli hastalarda testislerin shear wave elastografi ile değerlendirilmesi AU - Dere, Osman AU - Karaaslan, Hüseyin PY - 2023 DA - September Y2 - 2023 DO - 10.16899/jcm.1330250 JF - Journal of Contemporary Medicine JO - J Contemp Med PB - Rabia YILMAZ WT - DergiPark SN - 2667-7180 SP - 729 EP - 734 VL - 13 IS - 5 LA - en AB - Aim: The aim of this study was to evaluate testicular stiffness by shear wave elastography (SWE) in patients with isolated hypogonadotropic hypogonadism (IHH) and to compare it with healthy controls.Methods: In this prospective study, 35 patients with IHH (group 1) and 40 healthy controls (group 2) were evaluated. These two groups were compared in terms of age, testicular volume, and SWE values. In a subsequent analysis, IHH patients were divided into 3 groups: those who were newly diagnosed and did not receive any treatment (group A), those who received testosterone replacement (group B), and those who received human chorionic gonadotrophin alpha (hCG) (group C). Testicular volumes and SWE values were also compared between these subgroups.Results: Testicular volumes were significantly lower in group 1 than in group 2 (p KW - isolated hypogonadotropic hypogonadism KW - testicular stiffness KW - male infertility KW - Shear Wave Elastography N2 - Amaç: Bu çalışmanın amacı, izole hipogonadotropik hipogonadizm (IHH) hastalarında testis sertliğini shear wave elastografi (SWE) ile değerlendirmek ve sağlıklı kontrollerle karşılaştırmaktı.Gereç ve Yöntem: Bu prospektif çalışmada IHH'li 35 hasta (grup 1) ve 40 sağlıklı kontrol (grup 2) değerlendirildi. Bu iki grup yaş, testis hacmi ve SWE değerleri açısından karşılaştırıldı. Daha sonra yapılan bir analizde IHH hastaları, yeni teşhis konulan ve herhangi bir tedavi almayanlar (A grubu), testosteron replasmanı uygulananlar (B grubu) ve human koryonik gonadotropin alfa (hCG) alanlar (C grubu) şeklinde üç gruba ayrıldı. Testis hacimleri ve SWE değerleri de bu alt gruplar arasında karşılaştırıldı.Bulgular: Testis hacimleri grup 1'de grup 2'ye göre anlamlı derecede düşüktü (p CR - 1. O'Shaughnessy PJ. Hormonal control of germ cell development and spermatogenesis. Semin Cell Dev Biol 2014;29:55-65. CR - 2. Lin J, Mao J, Wang X, et al. Optimal treatment for spermatogenesis in male patients with hypogonadotropic hypogonadism. Medicine (Baltimore) 2019;98:e16616. CR - 3. Kwon A, Kim HS. Congenital hypogonadotropic hypogonadism: from clinical characteristics to genetic aspects. Precis Future Med 2021;5:97– 105. CR - 4. Young J, Xu C, Papadakis GE, et al. Clinical Management of Congenital Hypogonadotropic Hypogonadism. Endocr Rev. 2019;40:669-710. CR - 5. 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