TY  - JOUR
T1  - The Effects of Dipeptidyl Peptidase-4 Inhibitors on Kidney Function in Advanced CKD
TT  - İleri Evre Kronik Böbrek Hastalarında, Dipeptidl Peptidaz-4 İnhibitörlerinin Böbrek Fonksiyonu Üzerindeki Etkisi
AU  - İslam, Mahmud
AU  - Genç, Ahmed Cihad
PY  - 2023
DA  - October
Y2  - 2023
DO  - 10.34084/bshr.1347133
JF  - Journal of Biotechnology and Strategic Health Research
JO  - J Biotechnol and Strategic Health Res
PB  - Deneysel, Biyoteknolojik, Klinik ve Stratejik Sağlık Araştırmaları Derneği
WT  - DergiPark
SN  - 2587-1641
SP  - 166
EP  - 173
VL  - 7
IS  - 3
LA  - en
AB  - Objective: This study aimed to investigate the effects of DPP-4 inhibitors on kidney function in type 2 diabetes mellitus patients with stages 3-5 chronic kidney disease, focusing on estimated glomerular filtration rate and proteinuria.Methods: This is a retrospective case-control design, and data were collected from a single hospital's software and the Turkish Ministry of Health's National Data Tracking System. Diabetic patients with T2DM and CKD stages 3-5 were included, with dipeptidyl peptidase-4 inhibitor users (n=118) and non-users (n=48) forming the intervention and control groups, respectively. Baseline demographics, clinical characteristics, and outcomes were compared between groups.Results: At baseline, both groups demonstrated similar age, gender distribution, body mass index, and eGFR. Over a 12-month follow-up, while slight improvements in eGFR were observed in the intervention group and minor reductions in the control group, these changes did not reach statistical significance (p>0.05). Proteinuria showed a stable trend in the intervention group, whereas a significant increase was noted in the control group (p=0.035). Age significantly correlated with eGFR (p
KW  - Chronic kidney disease
KW  - DPP-4 inhibitors
KW  - eGFR
KW  - proteinuria
KW  - type 2 DM.
N2  - Amaç: Bu çalışmada, tahmini glomerüler filtrasyon hızı ve proteinüriye odaklanarak, evre 3-5 kronik böbrek hastalığı olan tip 2 diabetes mellitus hastalarında Dipeptidl Peptidaz-4  nhibitörlerinin böbrek fonksiyonu üzerindeki etkilerini araştırmayı amaçladık.Yöntemler: Çalışma retrospektif vaka kontrol olarak tasarlandı. Veriler tek bir hastanenin yazılımından ve T.C. Sağlık Bakanlığı Ulusal Veri Takip Sisteminden toplanmıştır. Hastalar, vildaglatin kullanan (Müdahele; n=118) ve kullanmayanlar (kontrol; n=48) tip 2 diyabet ve aynı zamanda evre 3-5 kronik böbrek hstalarında oluşturuldu. Temel demografik özellikler, klinik özellikler ve sonuçlar gruplar arasında karşılaştırıldı.Bulgular: Başlangıçta, her iki grup da benzer yaş, cinsiyet dağılımı, vücut kitle indeksi ve tGFH gösterdi. 12 aylık takipte, müdahale grubunda tGFH'da hafif iyileşmeler ve kontrol grubunda hafif azalmalar gözlenirken, bu değişiklikler istatistiksel olarak anlamlı bulunmadı (p>0,05). Proteinüri müdahale grubunda istikrarlı bir eğilim gösterirken, kontrol grubunda anlamlı bir artış kaydedildi (p=0,035). Yaş, tGFH ile anlamlı korelasyon gösterirken (p
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UR  - https://doi.org/10.34084/bshr.1347133
L1  - https://dergipark.org.tr/en/download/article-file/3350010
ER  -