@article{article_1361591, title={Protective Role of Pistacia Palaestina Boiss Fruit and Leaf Extracts in Isoproterenol-Induced Cardiac Ischemia}, journal={Fabad Eczacılık Bilimler Dergisi}, volume={49}, pages={181–196}, year={2024}, DOI={10.55262/fabadeczacilik.1361591}, author={İçen, Mehmet Sina and Yüce, Hande and Başak Türkmen, Neşe and Taşlıdere, Aslı and Aşkın Özek, Dilan and Ünüvar, Songül}, keywords={pistacia palaestina boiss, myocardial infarction, isoproterenol, oxidative stress, inflammation, phytotherapeutics}, abstract={Myocardial infarction (MI) is one of the leading causes of death worldwide. In this study aimed to investigate the protective effects of Pistacia palaestina Boiss (PP) leaf and fruit extracts, which are thought to have antioxidant and anti-inflammatory properties, in isoproterenol (ISO)-induced MI. 80 Spraque-Dawley rats were divided into 10 groups. The control group was given saline. PP leaf and fruit extracts at doses of 250 mg/kg and 500 mg/kg applied by gavage for 21 days. ISO 100 mg/kg subcutaneously was administered to the MI and MI-treatment groups on the 17th and 18th days of the experiment. Thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) levels, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were measured in heart tissue. In serum, Troponin t, CK-MB; pro-inflammatory cytokine necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β) and IL-6; Anti-inflammatory IL-10 levels were determined by the ELISA method. Heart tissue was examined by haematoxylin-eosin staining. While lipid peroxidation indicator TBARS activity increased in the MI group, antioxidant enzyme activities and GSH levels decreased. While Troponin t, CK-MB, TNF-α, IL-1β and IL-6 levels increased, anti-inflammatory IL-10 levels decreased. Low and high dose PP leaf and fruit extracts significantly decreased TBARS, Troponin t, CK-MB, TNF-α, IL-1β, IL-6 levels, improved antioxidant enzyme activity, GSH and IL-10 levels. PP ameliorated cardiac biomarkers and histopathological changes in ISO-induced MI by suppressing oxidative stress and inflammation. PP extracts may play an important cardioprotective role in the treatment of MI with their antioxidant and anti-inflammatory effects.}, number={1}, publisher={FABAD Ankara Eczacılık Bilimleri Derneği}, organization={This study was supported by IUBAP (İnönü University Scientific Research Project Unit) numbered TSA-2020-2146.}