TY  - JOUR
T1  - Inhibition of carbonic anhydrase and cholinesterase enzymes by acetone extract of Bryoria capillaris (Ach.) Brodo & D.Hawksw.
TT  - Inhibition of carbonic anhydrase and cholinesterase enzymes by acetone extract of Bryoria capillaris (Ach.) Brodo & D.Hawksw.
AU  - Karagöz, Yalçın
AU  - Uzun, Naim
AU  - Alparslan, Bayram
AU  - Şentürk, Murat
PY  - 2024
DA  - February
DO  - 10.21448/ijsm.1368533
JF  - International Journal of Secondary Metabolite
JO  - Int. J. Sec. Metabolite
PB  - İzzet KARA
WT  - DergiPark
SN  - 2148-6905
SP  - 105
EP  - 112
VL  - 11
IS  - 1
LA  - en
AB  - In traditional medicine, people commonly consume Bryoria capillaris (BC) as flour and tea, particularly in Northeast Anatolia, where it is one of the most prevalent lichen species. This study aimed to obtain an acetone extract of BC and investigate its inhibitory effects on carbonic anhydrase (CA) I, CA II, acetylcholine esterase (AChE), and butyrylcholine esterase (BChE) enzymes. We determined IC50 values of BC for each enzyme to measure the level of inhibition. The IC50 values for CA I and CA II were 8.77 μg/mL and 7.56 μg/mL, respectively. Acetazolamide, a specific CA I and II inhibitor, had IC50 values of 1.65 and 0.016 μg/mL, respectively. The IC50 values of BC for AChE and BChE were 7.96 and 8.58 μg/mL, respectively. Galantamine had IC50 values of 4.68 and 16.07 μg/mL for AChE and BChE, respectively. These results indicate that BC extract has a high potential to provide new drug candidates for all the tested enzymes, particularly for BChE.
KW  - Lichen
KW  - Enzyme
KW  - Bryoria capillaris
KW  - Inhibition
KW  - Cholinesterase
KW  - Carbonic anhydrase
N2  - In traditional medicine, people commonly consume Bryoria capillaris (BC) as flour and tea, particularly in Northeast Anatolia, where it is one of the most prevalent lichen species. This study aimed to obtain an acetone extract of BC and investigate its inhibitory effects on carbonic anhydrase (CA) I, CA II, acetylcholine esterase (AChE), and butyrylcholine esterase (BChE) enzymes. We determined IC50 values of BC for each enzyme to measure the level of inhibition. The IC50 values for CA I and CA II were 8.77 μg/mL and 7.56 μg/mL, respectively. Acetazolamide, a specific CA I and II inhibitor, had IC50 values of 1.65 and 0.016 μg/mL, respectively. The IC50 values of BC for AChE and BChE were 7.96 and 8.58 μg/mL, respectively. Galantamine had IC50 values of 4.68 and 16.07 μg/mL for AChE and BChE, respectively. These results indicate that BC extract has a high potential to provide new drug candidates for all the tested enzymes, particularly for BChE.
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UR  - https://doi.org/10.21448/ijsm.1368533
L1  - https://dergipark.org.tr/en/download/article-file/3443001
ER  -