@article{article_1371505, title={Clinical characteristics of patients with ectopic pregnancies treated with repeated doses of methotrexate.}, journal={Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi}, volume={57}, pages={49–52}, year={2024}, DOI={10.20492/aeahtd.1371505}, author={Kurtay, Sabri and Doğan Yangır, Gamze and Gözüküçük, Murat and Ustun, Yusuf}, keywords={Beta-human chorionic gonadotropin, Ectopic pregnancy, Methotrexate}, abstract={ABSTRACT Aim: Dose regimens of methotrexate used in the medical treatment of ectopic pregnancy vary. In this study, factors determining single-dose and repeated-dose methotrexate regimens were investigated. Material and methods: Patients diagnosed with ectopic pregnancy and treated with methotrexate in a tertiary care center were retrospectively analyzed. Medical characteristics, ultrasonography findings, and laboratory values of patients treated with single-dose methotrexate (n=128) and patients treated with additional doses (n=30) were compared. p <0.05 was considered significant. Results: There was no significant difference between the patient and medical characteristics. The need for additional dose was less in patients with more pelvic fluid on ultrasonography (p <0.001). Patients with a day 4/day 1 β-hcg ratio of 0.8474 and above required an additional dose of methotrexate (p <0.001). Discussion: Different parameters have been defined for patient selection for effective medical treatment of ectopic pregnancy. In this study, the effects of ultrasonography findings and β-hcg levels at follow-up on patient selection were quantitatively determined. Conclusion: The combination of day 4/day 1 β-hcg ratio and ultrasonography findings may help to identify patients in need of additional doses of methotrexate.}, number={2}, publisher={Sağlık Bakanlığı Ankara Eğitim ve Araştırma Hastanesi}