@article{article_1371823, title={Efficacy of Taxifolin in The Prevention of Renal Injury Due to Liver Ischemia and Reperfusion}, journal={Journal of Cukurova Anesthesia and Surgical Sciences}, volume={6}, pages={503–507}, year={2023}, DOI={10.36516/jocass.1371823}, author={Ülger, Burak Veli and Aşır, Fırat and Varlı, Metin and Gündüz, Ercan and Durgun, Hasan Mansur}, keywords={liver ischemia and reperfusion, taxifolin, histopathology, immunohistochemistry, oxidative stress}, abstract={Aim: During surgical procedures such as liver resection and transplantation, ischemia/reperfusion (I/R) injury and related complications may occur at a rate of approximately 10%. Our study, we planned to investigate histologically and biochemically the efficacy of Taxifolin in the prevention of renal tissue damage in liver ischemia reperfusion.
Methods: A total of 28 Wistar Albino rats with an average age of 8-10 weeks and weights of 250-300 grams were used in our study. Group 1 (n=7): control group, Group 2 (n=7): Taxifolin group; Taxifolin was administered orally at a dose of 50 mg/kg for 3 weeks, Group 3 (n=7): Liver I/R group, 30 minutes ischemia and 120 minutes reperfusion was performed. Group 4 (n=7): Taxifolin+Liver I/R group.
Results: Kidney tissues of the liver I/R group showed atrophy, degeneration of tubule epithelium and increased TNF-α expression. In addition, deterioration in renal function tests was also monitored in this group. In the Taxifolin+Liver I/R group, a significant difference was observed on both histologic and biochemical basis compared to the Liver I/R group and a positive effect was observed (p<0.05).
Outcome: As a consequence of hepatic ischemia and reperfusion, impairment in the function and histological appearance of renal tissues was observed and Taxifolin was monitored to be effective in eliminating these adverse effects.}, number={3}, publisher={Merthan TUNAY}