@article{article_1371936, title={Synthesis of Some New 1,3,4-Thiadiazole Derivatives Derived from Cholic Acid and Evaluation of their Biological Activity}, journal={Journal of the Turkish Chemical Society Section A: Chemistry}, volume={11}, pages={425–432}, year={2024}, DOI={10.18596/jotcsa.1371936}, author={Alaraj, Intisar Q M and Saeed, Rana A. and Reyadh, Linda and Ahmed, Amena A.}, keywords={Cholic acid, heterocyclic, Schiff bases, thiadiazoles, oxadiazoles, pathogenic bacteria}, abstract={In this work, several oxadiazole, thiadiazole, and triazole derivatives, as well as new Schiff bases, were prepared. Cholic acid was used as a starting material to prepare the five-membered heterocyclic compounds. The synthesized compounds were identified by FTIR and 1H,13C-NMR spectroscopy, which elucidated and confirmed the structure of the target molecules. Estimation of the biological activity of the newly produced compounds has been conducted against two types of Gram-positive and Gram-negative pathogenic bacteria.}, number={2}, publisher={Turkish Chemical Society}