@article{article_1373918, title={Effects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicity}, journal={Adıyaman Üniversitesi Sağlık Bilimleri Dergisi}, volume={10}, pages={1–9}, year={2024}, DOI={10.30569/adiyamansaglik.1373918}, author={Akgül, Nadir Bilgin and Üremiş, Muhammed Mehdi and Üremiş, Nuray and Annaç, Ebru and Bozat, Rıfat Cesur and Koca, Murat and Özkaya, Ahmet and Yanılmaz, Elif Merve Betül}, keywords={Bisphenol A, Coumarin, Kidney, Antioxidant, Oxidative stres}, abstract={Aim: In this study, it was aimed to investigate the protective effect of the synthesized coumarin ethyl 7-hydroxy-2-imino-2H-chromene-3 carboxylate (CM) against the renal toxicity of Bisphenol A (BPA).
Materials and Methods: The CM molecule was synthesised through the reaction between 2,4-dihydroxybenzaldehyde and ethyl cyanoacetate. Experiment was conducted in four groups of rats: control, BPA, CM, and BPA+CM. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), and Malondialdehyde (MDA) levels in kidney tissue were evaluated. serum samples were analyzed for Total-Native thiol and kidney function test parameters.
Results: The BPA-treated group exhibited significant decreases in TAS and thiol levels, increases in TOS and MDA levels. However, these side effects were significantly reduced with CM.
Conclusion: results obtained in this study indicate that CM molecule has a protective effect against BPA induced kidney toxicity.}, number={1}, publisher={Adıyaman University}, organization={This study was supported by Adiyaman University Scientific Research Projects Unit (ADYUBAP, Project no. TIPFMAP/2022-0008)}