@article{article_1386566, title={Analysis of Prognostic Factors in Malignancies of Gynecological Origin with Brain Metastases}, journal={Türk Jinekolojik Onkoloji Dergisi}, volume={23}, pages={1–8}, year={2023}, author={Eryılmaz, Tahir and Akıllı, Hüseyin and Ayhan, Ali and Ağıldere, Ahmet Muhteşem}, keywords={Gynecologic malignancy, Brain metastasis, Prognostic Factor, Radiotherapy}, abstract={Objective: We aimed to evaluate the demographic and clinical characteristics of patients diagnosed with brain metastases of gynecological origin and to analyze the factors affecting prognosis after the diagnosis of brain metastases. Material and Methods: Forty-eight patients with brain metastases who were followed for gynecological cancer in Başkent University’s Department of Gynecological Oncology between 2008 and 2021 were evaluated retrospectively. Demographic, clinical, and pathological characteristics of the patients and the distribution of treatments according to gynecological cancers since the time of primary diagnosis were noted. Median survival times after the diagnosis of brain metastasis were evaluated statistically. Prognostic factors affecting the process of brain metastasis and survival after diagnosis were statistically analyzed. Results: The median survival time after the diagnosis of brain metastasis was 8 months. It was 12 months in cases of ovarian cancer, 4 months for endometrial cancer, 8 months for cervical cancer, 3 months for vulvar cancer, and 4 months for uterine sarcomas. In univariate analysis, lesion number, localization, extracranial metastasis status, and treatment method were found to be associated with survival after brain metastasis, while lesion localization and treatment method were independent variables affecting prognosis in multivariate analysis. Conclusion: Patients with the best prognosis after brain metastasis were treated with combined therapy. However, stereotactic brain radiotherapy alone had a better prognosis compared to patients who received whole brain radiotherapy alone.}, number={2}, publisher={Türk Jinekolojik Onkoloji Derneği}