TY  - JOUR
T1  - A Case of Thalassemia Intermedia with Extramedullary Hematopoiesis Finding on FDG-PET/CT
AU  - Gümüş, Adil
AU  - Yavan, Gökçe
AU  - Kara, Pelin Özcan
AU  - Koç, Zehra Pınar
PY  - 2023
DA  - December
Y2  - 2023
JF  - Molecular Oncologic Imaging
PB  - Mersin University
WT  - DergiPark
SN  - 2791-965X
SP  - 12
EP  - 14
VL  - 3
IS  - 3
LA  - en
AB  - Extramedullary hematopoiesis is a physiological compensatory event that develops in hematological diseases characterized by hemolysis such as thalassemia, sickle cell anemia, myelofibrosis, hereditary spherocytosis, as a result of the insufficiency of the bone marrow in meeting the need for circulation. Intrathoracic extramedullary hematopoiesis is a rare condition. In this study, we present a 49-year-old male patient who was followed up by the hematology clinic due to thalassemia intermedia, and who underwent PET-CT examination for metabolic characterization after detecting a mass located in the paravetebral area in the posterior mediastinum.
KW  - FDG
KW  - PET/CT
KW  - intrathoracic extramedullary hematopoiesis
KW  - thalassemia intermedia
CR  - Taher, A., Isma'eel, H., & Cappellini, M. D. (2006). Thalassemia intermedia: revisited. Blood cells, molecules & diseases, 37(1), 12–20. https://doi.org/10.1016/j.bcmd.2006.04.005
CR  - Dore, F., Cianciulli, P., Rovasio, S., Oggiano, L., Bonfigli, S., Murineddu, M., Pardini, S., Simonetti, G., Gualdi, G., & Papa, G. (1992). Incidence and clinical study of ectopic erythropoiesis in adult patients with thalassemia intermedia. Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna, 7(3), 137–140
CR  - Aessopos, A., Tassiopoulos, S., Farmakis, D., Moyssakis, I., Kati, M., Polonifi, K., & Tsironi, M. (2006). Extramedullary hematopoiesis-related pleural effusion: the case of beta-thalassemia. The Annals of thoracic surgery, 81(6), 2037–2043. https://doi.org/10.1016/j.athoracsur.2006.01.026
CR  - Chuang, C. K., Chu, S. H., Fang, J. T., & Wu, J. H. (1998). Adrenal extramedullary hematopoietic tumor in a patient with beta-thalassemia. Journal of the Formosan Medical Association = Taiwan yi zhi, 97(6), 431–433
CR  - Kumar, A., Aggarwal, S., & de Tilly, L. N. (1995). Case of the season. Thalassemia major with extramedullary hematopoiesis in the liver. Seminars in roentgenology, 30(2), 99–101
CR  - Brannan D. Extramedullary hematopoiesis in anemias. Bull Johns Hopkins Hosp. 1927;41:104-135
CR  - Ross, P., & Logan, W. (1969). Roentgen findings in extramedullary hematopoiesis. The American journal of roentgenology, radium therapy, and nuclear medicine, 106(3), 604–613 https://doi.org/10.2214/ajr.106.3.604
CR  - Logothetis, J., Constantoulakis, M., Economidou, J., Stefanis, C., Hakas, P., Augoustaki, O., Sofroniadou, K., Loewenson, R., & Bilek, M. (1972). Thalassemia major (homozygous beta-thalassemia). A survey of 138 cases with emphasis on neurologic and muscular aspects. Neurology, 22(3), 294–304. https://doi.org/10.1212/wnl.22.3.294
CR  - Prabhakar, S., Chopra, J. S., Khosla, V. K., Dash, S., & Banerjee, A. K. (1980). Spinal cord compression in homozygous beta thalassaemia. Surgical neurology, 13(5), 351–354
CR  - Shin, K. H., Sharma, S., Gregoritch, S. J., Lifeso, R. M., Bettigole, R., & Yoon, S. S. (1994). Combined radiotherapeutic and surgical management of a spinal cord compression by extramedullary hematopoiesis in a patient with hemoglobin E beta-thalassemia. Acta haematologica, 91(3), 154–157. https://doi.org/10.1159/000204322
CR  - Salehi, S. A., Koski, T., & Ondra, S. L. (2004). Spinal cord compression in beta-thalassemia: case report and review of the literature. Spinal cord, 42(2), 117–123. https://doi.org/10.1038/sj.sc.3101544
CR  - Haidar, R., Mhaidli, H., & Taher, A. T. (2010). Paraspinal extramedullary hematopoiesis in patients with thalassemia intermedia. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 19(6), 871–878. https://doi.org/10.1007/s00586-010-1357-2
CR  - An, J., Weng, Y., He, J., Li, Y., Huang, S., Cai, S., Zhang, J."Intrathoracic extramedullary hematopoiesis presenting as tumor simulating lesions of the mediastinum in α thalassemia: A case report". Oncology Letters 10, no. 4 (2015): 1993-1996. https://doi.org/10.3892/ol.2015.3597
CR  - Dahlsgaard-Wallenius, S. E., Juul-Jensen, K., Nielsen, A. L., & Hildebrandt, M. G. (2022). Extramedullary Hematopoiesis Visualized on FDG-PET/CT in a Patient with Beta-Thalassemia. Nuclear medicine and molecular imaging, 56(6), 328–330. https://doi.org/10.1007/s13139-022-00773-3
UR  - https://dergipark.org.tr/en/pub/moi/issue//1401763
L1  - https://dergipark.org.tr/en/download/article-file/3585735
ER  -