TY - JOUR T1 - Investigation of the Antitumoral Activity of Syringic Acid on HT-29 Cells: An In Vitro Study AU - Altunlu, Öznur AU - Burul, Feyza AU - Ferah Okkay, Irmak AU - Bayram, Cemil AU - Yesilyurt, Fatma AU - Okkay, Ufuk PY - 2023 DA - December Y2 - 2023 JF - Recent Trends in Pharmacology JO - Recent Trends in Pharmacology PB - Ataturk University WT - DergiPark SN - 2980-194X SP - 123 EP - 130 VL - 1 IS - 3 LA - en AB - AbstractColorectal cancer (CRC) is one of the most common cancers in the world with high mortality rates, and it is the second leading cause of cancer-related deaths worldwide and it is estimated that more than 930,000 deaths will occur due to CRC. In addition to genetic and environmental factors, oxidative stress, lipid peroxidation and parameter changes in the antioxidant system are among the risk factors. Syringic acid (SA) which contains polyphenolic compounds, has antioxidant, anti-lipid peroxidative and anti-cancer effects. Due to these effects, syringic acid may have a healing effect on HT-29 cells. In our study, we determined the effect of SA on cell viability on HT-29 cells with MTT, and its effects on antioxidant and oxidant parameters with TAC-TOS tests. Syringic acid decreased viability, increased TAC levels and did not cause a significant change in TOS levels in HT-29 cells. These findings may indicate that SA has curative effects on CRC. However, more studies are needed for clinical uses. KW - Anticancer KW - Antioxidant KW - Colorectal cancer KW - HT-29 Cells KW - Syringic acid CR - Abaza, M.-S., Al-Attiyah, R. a., Bhardwaj, R., Abbadi, G., Koyippally, M., & Afzal, M. (2013). Syringic acid from Tamarix aucheriana possesses antimitogenic and chemo-sensitizing activities in human colorectal cancer cells. Pharmaceutical Biology, 51(9), 1110-1124. https://doi.org/10.3109/13880209.2013.781194 CR - Ahmed, M. (2020). Colon Cancer: A Clinician's Perspective in 2019. 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