TY  - JOUR
T1  - Effects of GDF-15 Level in Patients with Membranous Nephropathy
AU  - Adıkozalova, Aıda
AU  - Usta Akgül, Sebahat
AU  - Demir, Erol
AU  - Şentürk Çiftçi, Hayriye
AU  - Oğuz, Fatma Savran
AU  - Yazıcı, Halil
AU  - Kekik Çınar, Çiğdem
PY  - 2024
DA  - April
Y2  - 2024
DO  - 10.26650/experimed.1403563
JF  - Experimed
PB  - Istanbul University
WT  - DergiPark
SN  - 2667-5846
SP  - 40
EP  - 45
VL  - 14
IS  - 1
LA  - en
AB  - Objective: Nephrotic syndrome is the most frequent cause of membranous nephropathy (MN) in adults. Growth differentiation factor (GDF)-15 is a cytokine released under stress and associated with increased incidence of chronic kidney disease and/or decreased renal function in conditions such as diabetic nephropathy, IgA nephropathy, lupus nephritis, and primary MN. The diagnosis of MN is made by biopsy, which is an invasive procedure. A non-invasive biomarker is needed for timely and risk-free diagnosis. This study aimed to estimate the GDF-15 level in patients with MN to determine if it can be used as a noninvasive biomarker for the diagnosis of MN.Materials and Methods: The study included 88 patients with MN. Sera were obtained from peripheral blood collected from the patients. GDF-15 levels were analyzed using enzyme-linked immunosorbent assay (ELISA).Results: GDF-15 level was high in older patients that in younger patients. The glomerular filtration rate was low in patients with increased GDF-15 levels. Furthermore, a decrease in GDF-15 levels was observed in patients in remission.Conclusion: GDF-15 level may be used as a biomarker to predict the progression of MN rather than a diagnostic biomarker.
KW  - Membranous nephropathy
KW  - GDF-15
KW  - ELISA
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UR  - https://doi.org/10.26650/experimed.1403563
L1  - https://dergipark.org.tr/en/download/article-file/3593765
ER  -