TY - JOUR T1 - The assessment of serum uric acid-to-HDL cholesterol ratio as a new predictor of mortality in ST-elevation myocardial infarction: a cross-sectional study TT - ST yükselmeli miyokard enfarktüsünde serum ürik asit-HDL kolesterol oranının mortalitenin yeni bir belirleyicisi olarak değerlendirilmesi: kesitsel bir çalışma AU - Genç, Ömer AU - Yıldırım, Abdullah AU - Özkan, Eyüp PY - 2024 DA - February Y2 - 2024 DO - 10.47582/jompac.1405773 JF - Journal of Medicine and Palliative Care JO - J Med Palliat Care / JOMPAC / jompac PB - MediHealth Academy Yayıncılık WT - DergiPark SN - 2717-7505 SP - 57 EP - 64 VL - 5 IS - 1 LA - en AB - Aims: The objective of this study was to evaluate the predictive efficacy of the Uric Acid-to-High Density Lipoprotein Cholesterol Ratio (UHR) as a novel inflammatory and metabolic marker for mortality in patients with ST-segment Elevation Myocardial Infarction (STEMI).Methods: This retrospective, single-center, cross-sectional, observational study enrolled 1361 patients diagnosed with STEMI undergoing primary percutaneous coronary intervention (PPCI) from March 2021, to January 2022. The participants were categorized into two groups: those experiencing in-hospital mortality (n=100) and those without in-hospital mortality (n=1265).Results: In-hospital mortality occurred in 100 patients (7.3%). UHR was notably higher in the mortality group compared to the non-mortality group (23.6±14.9% vs. 15.3±6.9%, p KW - Uric acid KW - HDL-C KW - uric acid-to-high density lipoprotein cholesterol ratio KW - STEMI KW - SYNTAX score KW - in-hospital mortality N2 - Giriş ve amaç: Bu çalışmanın amacı, ST-segment Yükselmeli Miyokard Enfarktüsü (STYME) geçiren hastalarda mortalite için yeni bir enflamatuar ve metabolik belirteç olarak Ürik Asit-Yüksek Dansiteli Lipoprotein Kolesterol Oranının (ÜHO) öngörücü etkinliğini değerlendirmektir.Yöntemler: Bu retrospektif, tek merkezli, kesitsel, gözlemsel çalışmaya Mart 2021 ile Ocak 2022 tarihleri arasında primer perkütan koroner girişim (PPKG) uygulanan STYMI tanılı 1361 hasta dahil edilmiştir. Katılımcılar iki gruba ayrılmıştır: hastane-içi mortalite gerçekleşen (n=100) ve gerçekleşmeyen (n=1265).Sonuçlar: Hastane-içi mortalite 100 hastada (%7.3) meydana gelmiştir. ÜHO, mortalite grubunda mortalite olmayan gruba kıyasla belirgin şekilde daha yüksekti (%23.6±14.9'a karşı %15.3±6.9, p CR - Mathers CD, Boerma T, Ma Fat D. Global and regional causes of death. Br Med Bull. 2009;92(1):7-32. CR - Anderson JL, Morrow DA. Acute myocardial infarction. NEJM. 2017;376(21):2053-2064. CR - Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-177. CR - Collet JP, Thiele H, Barbato E, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2021;42(14):1289-1367. CR - Zeymer U, Ludman P, Danchin N, et al. Reperfusion therapies and in-hospital outcomes for ST-elevation myocardial infarction in Europe: the ACVC-EAPCI EORP STEMI Registry of the European Society of Cardiology. Eur Heart J. 2021;42(44):4536-4549. CR - Chuang SY, Chen JH, Yeh WT, Wu CC, Pan WH. Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort. Int J Cardiol. 2012;154(3):316-321. CR - Li L, Zhao M, Wang C, et al. Early onset of hyperuricemia is associated with increased cardiovascular disease and mortality risk. Clin Res Cardiol. 2021;110(7):1096-1105. CR - Goldbourt U, Yaari S, Medalie JH. Isolated low HDL cholesterol as a risk factor for coronary heart disease mortality: a 21-year follow-up of 8000 men. Arterioscler Thromb. 1997;17(1):107-113. CR - Yu S, Guo X, Li GX, Yang H, Zheng L, Sun Y. Lower or higher HDL-C levels are associated with cardiovascular events in the general population in rural China. Lipids Health Dis. 2020;19(1):1-6. CR - Kosekli MA, Kurtkulagii O, Kahveci G, et al. The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: the abund study. Rev Assoc Med Bras. 2021;67:549-554. CR - Zhou Y, Wei F, Fan Y. High serum uric acid and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis. Clin Biochem. 2016;49(7-8):636-642. CR - Kocak MZ, Aktas G, Erkus E, Sincer I, Atak B, Duman T. Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus. Rev Assoc Med Bras. 2019;65(1):9-15. CR - Zhang YN, Wang QQ, Chen YS, Shen C, Xu CF. Association between serum uric acid to hdl-cholesterol ratio and nonalcoholic fatty liver disease in lean chinese adults. Int J Endocrinol. 2020;2020:5953461. CR - Kurtkulagi O, Tel BMA, Kahveci G, et al. Hashimoto’s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio. Rom J Intern Med. 2021;59(4):403-408. CR - Aktas G, Kocak MZ, Bilgin S, Atak BM, Duman TT, Kurtkulagi O. Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. Aging Male. 2020;23(5):1098-1102. CR - Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention. 2005;1(2):219-227. CR - Granger CB, Goldberg RJ, Dabbous O, et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163(19):2345-2353. CR - Stolt Steiger V, Goy JJ, Stauffer JC, et al. Significant decrease in in-hospital mortality and major adverse cardiac events in Swiss STEMI patients between 2000 and December 2007. Swiss Med Wkly. 2009;139(31-32):453-457. CR - Cretu DE, Udroiu CA, Stoicescu CI, Tatu-Chitoiu G, Vinereanu D. Predictors of in-hospital mortality of ST-segment elevation myocardial infarction patients undergoing interventional treatment. An analysis of data from the RO-STEMI registry. Maedica. 2015;10(4):295-303. CR - Gale CP, Manda S, Batin PD, Weston CF, Birkhead JS, Hall AS. Predictors of in-hospital mortality for patients admitted with ST-elevation myocardial infarction: a real-world study using the Myocardial Infarction National Audit Project (MINAP) database. Heart. 2008;94(11):1407-1412. CR - Alves L, Ziegelmann PK, Ribeiro V, Polanczyk C. Hospital mortality from myocardial infarction in Latin America and the Caribbean: systematic review and meta-analysis. Arq Bras Cardiol. 2022;119(6):970-978. CR - Xu Y, Zhu J, Gao L, et al. Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients: a meta-analysis. PloS One. 2013;8(10):e78206. CR - Mortada I. Hyperuricemia, type 2 diabetes mellitus, and hypertension: an emerging association. Curr Hypertens Rep. 2017; 19(9):69. CR - Cheng KH, Chu CS, Lin TH, Lee KT, Sheu SH, Lai WT. Lipid paradox in acute myocardial infarction—the association with 30-day in-hospital mortality. Crit Care Med. 2015;43(6):1255-1264. CR - Reddy VS, Bui QT, Jacobs JR, Begelman SM, Miller DP, French WJ. Relationship between serum low-density lipoprotein cholesterol and in-hospital mortality following acute myocardial infarction (the lipid paradox). Am J Cardiol. 2015;115(5):557-562. CR - Ji MS, Jeong MH, Ahn YK, et al. Impact of low level of high-density lipoprotein-cholesterol sampled in overnight fasting state on the clinical outcomes in patients with acute myocardial infarction (difference between ST-segment and non-ST-segment-elevation myocardial infarction). J Cardiol. 2015;65(1):63-70. CR - Yang Y, Zhang J, Jia L, Su J, Ma M, Lin X. The interaction between uric acid and high-density lipoprotein cholesterol on the prognosis of patients with acute myocardial infarction. Front Cardiovasc Med. 2023;10:1226108. CR - Hu X, Liu J, Li W, et al. Elevated serum uric acid was associated with pre-inflammatory state and impacted the role of HDL-C on carotid atherosclerosis. Nutr Metab Cardiovasc Dis. 2022;32(7):1661-1669. CR - Mansiroglu AK, Cekici Y, Sincer I, Gunes Y. Serum uric acid and uric acid to HDL-cholesterol ratio in coronary artery fistulas. Ann Med Res. 2019;26(12):2771-2775. CR - Aydın C, Emlek N. The relationship between uric acid to high-density lipoprotein cholesterol ratio and collateral index in patients with chronic total occlusion. Kardiologiia. 2021;61(9):61-65. CR - Li F, Zhao D, Li Q, Lin X, Sun H, Fan Q. Uric acid to high-density lipoprotein cholesterol ratio is a novel marker to predict functionally significant coronary artery stenosis. J Interv Cardiol. 2022;2022:9057832. CR - Rencuzogullari I, Çağdaş M, Karakoyun S, et al. Association of Syntax Score II with contrast-induced nephropathy and hemodialysis requirement in patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Korean Circ J. 2018;48(1):59-70. CR - Alıcı G, Barman HA, Atıcı A, Tuğrul S, Genç Ö, Şahin İ. The impact of lesion complexity and the CHA 2 DS 2-VASc score on spontaneous reperfusion in patients with ST-segment elevation myocardial infarction. Int J Clin Pract. 2022;2022:8066780. CR - Cirakoglu OF, Aslan AO, Akyuz AR, et al. The value of syntax score to predict new‐onset atrial fibrillation in patients with acute coronary syndrome. Ann Noninvasive Electrocardiol. 2019;24(4):e12622. CR - Kul S, Akgul O, Uyarel H, et al. High SYNTAX score predicts worse in-hospital clinical outcomes in patients undergoing primary angioplasty for acute myocardial infarction. Coron Artery Dis. 2012;23(8):542-548. CR - Alıcı G, Genç Ö, Urgun ÖD, et al. The value of PRECISE-DAPT score and lesion complexity for predicting all-cause mortality in patients with NSTEMI. Egypt Heart J. 2023;75(1):1-7. CR - Ali M, Lange S, Wittlinger T, Lehnert G, Rigopoulos A, Noutsias M. In-hospital mortality after acute STEMI in patients undergoing primary PCI. Herz. 2018;43(8):741-745. CR - Sanguanwong S, Srimahachota S, Tungsubutra W, Srichaiveth B, Kiatchoosakun S. Predictors of in-hospital mortality in Thai STEMI patients: results from TACSR. J Med Assoc Thai. 2007;90(Suppl 1):91-97. CR - Almeida I, Miranda H, Santos H, et al. Prognostic value of BNP in STEMI patients. Eur Heart J Acute Cardiovasc Care. 2021;10(Supplement_1):zuab020-093. CR - Akgul O, Uyarel H, Pusuroglu H, et al. High BNP level as risk factor for acute kidney injury and predictor of all-cause mortality in STEMI patients. Herz. 2014;39(4):507-514. CR - Caputo RP, Goel A, Pencina M, et al. Impact of drug eluting stent length on outcomes of percutaneous coronary intervention (from the EVENT registry). Am J Cardiol. 2012;110(3):350-355. CR - Konishi H, Miyauchi K, Dohi T, et al. Impact of stent length on clinical outcomes of first-generation and new-generation drug-eluting stents. Cardiovasc Interv Ther. 2016;31(2):114-121. CR - Moghaddam N, Wong GC, Cairns JA, et al. Association of anemia with outcomes among ST-segment–elevation myocardial infarction patients receiving primary percutaneous coronary intervention. Circ Cardiovasc Interv. 2018;11(12):e007175. CR - Rousan TA, Pappy RM, Chen AY, Roe MT, Saucedo JF. Impact of diabetes mellitus on clinical characteristics, management, and in-hospital outcomes in patients with acute myocardial infarction (from the NCDR). Am J Cardiol. 2014;114(8):1136-1144. UR - https://doi.org/10.47582/jompac.1405773 L1 - https://dergipark.org.tr/en/download/article-file/3603298 ER -