@article{article_1413088, title={The Relationship Between Hematological Inflammatory Markers and Postoperative Hypocalcemia in Patients with Primary Hyperparathyroidism}, journal={Medical Journal of Süleyman Demirel University}, volume={31}, pages={205–211}, year={2024}, DOI={10.17343/sdutfd.1413088}, author={Gezer, Emre and Zekey, Ömer and Yaprak Bayrak, Büşra and Cantürk, Zeynep and Çetinarslan, Berrin and Selek, Alev and Sözen, Mehmet and Köksalan, Damla}, keywords={Hyperparathyroidism, Hypocalcemia, Neutrophils, Lymphocytes, Platelets}, abstract={Objective: Primary hyperparathyroidism (PHPT) is a common endocrine disease that is characterized by hypercalcemia and commonly associated with parathyroid adenoma (PTA). Hypocalcemia is a common postoperative complication in patients with PHPT. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are inexpensive hematological inflammatory markers. We aimed to investigate the potential predictive risk factors, including the hemogram-derived inflammatory markers for early postoperative hypocalcemia in patients with PHPT. Material and Method: Patients diagnosed with PHPT, underwent parathyroidectomy and histopathologically shown to be caused by a single PTA were included. Results: NLR was significantly correlated with parathormone (PTH), while PLR was related considerably with only NLR. A significant positive correlation was shown between gland weight, volume, calcium (Ca), and PTH levels. A significant correlation of postoperative hypocalcemia with age, preoperative Ca, PTH, and NLR was also demonstrated. Conclusion: We found that NLR was significantly higher in patients with PHPT who developed postoperative hypocalcemia; however, our regression analysis did not find elevated NLR as a significant predictive risk factor for postoperative hypocalcemia. To the best of our knowledge, this is the first study investigating the relationship between hemogram-derived inflammatory markers and clinical parameters, such as the development of postoperative hypocalcemia and preoperative nephrolithiasis, in patients with PHPT. Keywords: Hyperparathyroidism, Hypocalcemia, Neutrophils, Lymphocytes, Platelets}, number={3}, publisher={Süleyman Demirel University}