TY  - JOUR
T1  - The effect of ginger essential oil (Zingiber officinale) on catalase in rat kidney tissue
AU  - Yıldız Asker, Yağmur
AU  - Aras, Şükran
AU  - Ölmez, Mükremin
AU  - Asker, Hasan
AU  - Makav, Mustafa
AU  - Gezer, Arzu
AU  - Şahin, Tarkan
PY  - 2024
DA  - August
Y2  - 2024
DO  - 10.31797/vetbio.1415244
JF  - Journal of Advances in VetBio Science and Techniques
JO  - J Ad VetBio Sci Tech
PB  - İlker ÇAMKERTEN
WT  - DergiPark
SN  - 2548-1150
SP  - 87
EP  - 95
VL  - 9
IS  - 2
LA  - en
AB  - We were aimed to investigate the effect of ginger essential oil (Zingiber officinale) on catalase release in rat kidney tissue by histopathological and immunohistochemically method. This study, 21 male Wistar albino rats were used. Rats were divided into three groups: control, 100 mg/kg ginger essential oil (G100), and 500 mg/kg ginger essential oil (G500). Hematoxylin-eosin staining method was used for histopathological evaluations. Immunohistochemically localization of catalase in kidney tissue was determined by streptavidin-biotin peroxidase method. As a result of histopathological evaluations, an increase in glomerulus diameter was observed in kidney tissues of G100 and G500 groups. In addition, vacuolar degeneration was observed in the proximal and distal tubule epithelial cells in the renal cortex of the G100 group. The immunoreactivity of catalase in the renal cortex region; In the control group, it is strong in the proximal tubules and weak in the mesangial cells. While moderate severity in the proximal tubules and weak in the mesangial cells in the G100 group, very weak catalase immunoreactivity was observed in the G500 group. Strong catalase immunoreactivity was detected in the proximal and collecting ducts of the kidney medulla regions of the rats in all groups. We think that ginger essential oil can be used in appropriate doses and times to reduce kidney damage caused by oxidative stress in the kidney.
KW  - Catalase
KW  - ginger essential oil
KW  - kidney
CR  - Ademiluyi, A. O., Oboh, G., Ogunsuyi, O. B., & Akinyemi, A. J. (2012). Attenuation of gentamycin-induced nephrotoxicity in rats by dietary inclusion of ginger (zingiber officinale) and turmeric (curcuma longa) rhizomes. Nutrition and Health, 21(4), 209-218. https://doi.org/10.1177/0260106013506668
CR  - Ajith, T. A., Aswathy, M. S., & Hema, U. (2008). Protective effect of zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity. Food and Chemical Toxicology, 46(9), 3178-3181. https://doi.org/10.1016/j.fct.2008.07.004
CR  - Akbulut, S., Elbe, H., Eris, C., Dogan, Z., Toprak, G., Otan, E., Erdemli, E., & Turkoz, Y. (2014). Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World Journal of Gastroenterology, 20(29), 10158-10165. https://doi.org/10.3748/wjg.v20.i29.10158
CR  - Al Hroob, A. M., Abukhalil, M. H., Alghonmeen, R. D., & Mahmoud, A. M. (2018). Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy. Biomedicine & Pharmacotherapy, 106, 381-389. https://doi.org/10.1016/j.biopha.2018.06.148
CR  - Albrakati, A. (2021). Aged garlic extract rescues ethephon-induced kidney damage by modulating oxidative stress, apoptosis, inflammation, and histopathological changes in rats. Environmental Science and Pollution Research, 28(6), 6818-6829. https://doi.org/10.1007/s11356-020-10997-5
CR  - Alonso-Alconada, D., Hilario, E., Alvarez, F. J., & Alvarez, A. (2012). Apoptotic cell death correlates with ROS overproduction and early cytokine expression after hypoxia-ischemia in fetal lambs. Reproductive Sciences, 19(7), 754-763. https://doi.org/10.1177/1933719111432868
CR  - Aras, Ş. Y., Doğan, G. K., & Sarı, E. K. (2023). An anatomical, histological, and immunohistochemical investigation on the intestines of the Eurasian lynx (Lynx lynx). The Thai Journal of Veterinary Medicine, 53(1), 97-108. https://doi.org/10.14456/tjvm.2023.10
CR  - Bakir, B., Erdag, D., Yildiz, S. E., Sari, E. K., Asker, H., & Sozmen, M. (2017). Immunohistochemical examination on the effects of malathion and onosma nigricaule (boraginaceae) on the catalase (CAT) and superoxide dismutase-2 (Mn-Sod) in renal tissues of mice. Ankara Universitesi Veteriner Fakultesi Dergisi, 64(2), 125-130. https://doi.org/10.1501/Vetfak_0000002785
CR  - Cayir, K., Karadeniz, A., Simsek, N., Yildirim, S., Karakus, E., Kara, A., Akkoyun, H. T., & Sengul, E. (2011). Pomegranate seed extract attenuates chemotherapy-induced acute nephrotoxicity and hepatotoxicity in rats. Journal of Medicinal Food, 14(10), 1254-1262. https://doi.org/10.1089/jmf.2010.0286
CR  - Chen, S. Y., Lee, Y. R., Hsieh, M. C., Omar, H. A., Teng, Y. N., Lin, C. Y., & Hung, J. H. (2018). Enhancing the anticancer activity of antrodia cinnamomea in hepatocellular carcinoma cells via cocultivation with ginger: The impact on cancer cell survival pathways. Frontiers in Pharmacology, 9, 780. https://doi.org/10.3389/fphar.2018.00780
CR  - Cuya, T., Baptista, L., & Celmar Costa Franca, T. (2018). A molecular dynamics study of components of the ginger (zingiber officinale) extract inside human acetylcholinesterase: Implications for alzheimer disease. Journal of Biomolecular Structure and Dynamics, 36(14), 3843-3855. https://doi.org/10.1080/07391102.2017.1401004
CR  - Fogo, A. B. (2000). Glomerular hypertension, abnormal glomerular growth, and progression of renal diseases. Kidney Int Suppl, 75, S15-S21.
CR  - Forbes, J. M., Coughlan, M. T., & Cooper, M. E. (2008). Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes, 57(6), 1446-1454. https://doi.org/10.2337/db08-0057
CR  - Galle, J. (2001). Oxidative stress in chronic renal failure. Nephrology Dialysis Transplantation, 16(11), 2135-2137. https://doi.org/10.1093/ndt/16.11.2135
CR  - Ghebreselassie, D., Mekonnen, Y., Gebru, G., Ergete, W., & Huruy, K. (2011). The effects of moringa stenopetala on blood parameters and histopathology of liver and kidney in mice. Ethiopian Journal of Health Development, 25(1), 51-57. https://doi.org/10.4314/ejhd.v25i1.69850
CR  - Gholampour, F., Ghiasabadi, F. B., Owji, S. M., & Vatanparast, J. (2017). The protective effect of hydroalcoholic extract of ginger (zingiber officinale rosc.) against iron-induced functional and histological damages in rat liver and kidney. Avicenna Journal of Phytomedicine, 7(6), 542-553. https://doi.org/10.22038/ajp.2017.22297.1831
CR  - Hsu, S. M., Raine, L., & Fanger, H. (1981). The Use of antiavidin antibody and avidin - Biotin - peroxidase complex in immunoperoxidase techniques. American Journal of Clinical Pathology, 75(6), 816-821. https://doi.org/10.1093/ajcp/75.6.816
CR  - Jeena, K., Liju, V. B., & Kuttan, R. (2011). A Preliminary 13-week oral toxicity study of ginger oil in male and female wistar rats. International Journal of Toxicology, 30(6), 662-670. https://doi.org/10.1177/1091581811419023
CR  - Karaali, H. F., Fahmi, R. R., & Borjac, J. M. (2018). Effect of Ocimum basilicum leaves extract on acetaminophen-induced nephrotoxicity in BALB/c mice. Journal of Complementary and Integrative Medicine, 16(2), 20180111. https://doi.org/10.1515/jcim-2018-0111
CR  - Karna, P., Chagani, S., Gundala, S. R., Rida, P. C., Asif, G., Sharma, V., Gupta, M. V., & Aneja, R. (2012). Benefits of whole ginger extract in prostate cancer. British Journal of Nutrition, 107(4), 473-484. https://doi.org/10.1017/S0007114511003308
CR  - Khleifat, K., Shakhanbeh, J., & Tarawneh, K. (2021). The chronic effects of teucrium polium on some blood parameters and histopathology of liver and kidney in the rat. Turkish Journal of Biology, 26(2), 65-71.
CR  - Kotyk, T., Dey, N., Ashour, A. S., Balas-Timar, D., Chakraborty, S., Ashour, A. S., & Tavares, J. M. (2016). Measurement of glomerulus diameter and Bowman's space width of renal albino rats. Computer Methods and Programs in Biomedicine, 126, 143-153. https://doi.org/10.1016/j.cmpb.2015.10.023
CR  - Kukula-Koch, W., Koch, W., Czernicka, L., Glowniak, K., Asakawa, Y., Umeyama, A., Marzec, Z., & Kuzuhara, T. (2018). Mao-a inhibitory potential of terpene constituents from ginger rhizomes-a bioactivity guided fractionation. Molecules, 23(6). https://doi.org/10.3390/molecules23061301
CR  - Lee, C. H., Park, J. H., Ahn, J. H., Kim, J. D., Cho, J. H., Lee, T. K., & Won, M. H. (2019). Stronger antioxidant enzyme immunoreactivity of populus tomentiglandulosa extract than ascorbic acid in rat liver and kidney. Iranian Journal of Basic Medical Sciences, 22(8), 963-967. https://doi.org/10.22038/ijbms.2019.34926.8296
CR  - Liu, D. F., Guo, M. Y., Hu, Y. H., Liu, T. H., Yan, J., Luo, Y., Yun, M. D., Yang, M., Zhang, J., & Guo, L. L. (2015). Effect of sanhuangwuji powder, anti-rheumatic drugs, and ginger-partitioned acupoint stimulation on the treatment of rheumatoid arthritis with peptic ulcer: A randomized controlled study. Journal of Traditional Chinese Medicine, 35(3), 273-280. https://doi.org/10.1016/S0254-6272(15)30097-2
CR  - Liu, Q., Liu, J. J., Guo, H. L., Sun, S. N., Wang, S. F., Zhang, Y. L., Li, S. Y., & Qiao, Y. J. (2013). [6]-Gingerol: A novel AT(1) antagonist for the treatment of cardiovascular disease. Planta Medica, 79(5), 322-326. https://doi.org/10.1055/s-0032-1328262
CR  - Nita, M., & Grzybowski, A. (2016). The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxidative Medicine and Cellular Longevity, 2016, 3164734. https://doi.org/10.1155/2016/3164734
CR  - Palipoch, S. (2013). A review of oxidative stress in acute kidney injury: Protective role of medicinal plants-derived antioxidants. African Journal of Traditional Complementary and Alternative Medicines, 10(4), 88-93. https://doi.org/10.4314/ajtcam.v10i4.15
CR  - Parveen, R., Azmi, M. A., Naqvi, S. N. H., Mahmood, S. M., & Zaidi, I. H. (2010). Effect of cedrus deodara (pinaceae) root oil on the histopathology of rat liver and kidney. Tropical Journal of Pharmaceutical Research, 9(2), 127-133. https://doi.org/10.4314/tjpr.v9i2.53699
CR  - Paul, C. W., & Didia, B. C. (2012). The effect of methanolic extract of moringa oleifera lam roots on the histology of kidney and liver of guinea pigs. Asian Journal of Medical Sciences, 4(1), 55-60.
CR  - Reddy, Y. A., Chalamaiah, M., Ramesh, B., Balaji, G., & Indira, P. (2014). Ameliorating activity of ginger (zingiber officinale) extract against lead induced renal toxicity in male rats. Journal of Food Science and Technology, 51(5), 908-914. https://doi.org/10.1007/s13197-011-0568-9
CR  - Sakr, A. S., Lamfon, A. H., & Essawy, E. A. (2011). Ginger (zingiber officinale) extract ameliorates metalaxyl fungicide induced nephrotoxicity in albino mice. African Journal of Pharmacy and Pharmacology, 5(2), 104-112. https://doi.org/10.5897/AJPP.9000163
CR  - Scibior, D., & Czeczot, H. (2006). Catalase: structure, properties, functions. Advances in Hygiene and Experimental Medicine, 60, 170-180.
CR  - Shaw, D. (2010). Toxicological risks of Chinese herbs. Planta Medica, 76(17), 2012-2018. https://doi.org/10.1055/s-0030-1250533
CR  - Shaw, D., Graeme, L., Pierre, D., Elizabeth, W., & Kelvin, C. (2012). Pharmacovigilance of herbal medicine. Journal of Ethnopharmacology, 140(3), 513-518. https://doi.org/10.1016/j.jep.2012.01.051
CR  - Suk, S., Kwon, G. T., Lee, E., Jang, W. J., Yang, H., Kim, J. H., Thimmegowda, N. R., Chung, M. Y., Kwon, J. Y., Yang, S., Kim, J. K., Park, J. H. Y., & Lee, K. W. (2017). Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. Molecular Nutrition & Food Research, 61(10). https://doi.org/10.1002/mnfr.201700139
CR  - Tae, H. J., Park, J. H., Cho, J. H., Kim, I. H., Ahn, J. H., Lee, J. C., Kim, J. D., Park, J., Choi, S. Y., & Won, M. H. (2014). Oenanthe javanica extract increases immunoreactivities of antioxidant enzymes in the rat kidney. Chinese Medical Journal, 127(21), 3758-3763. https://doi.org/10.3760/cma.j.issn.0366-6999.20141863
CR  - Yu, H. J., Ge, Y., Wang, Y., Lin, C. T., Li, J., Liu, X. M., Zang, T. Z., Xu, J. Y., Liu, J. Q., Luo, G. M., & Shen, J. C. (2007). A fused selenium-containing protein with both GPx and SOD activities. Biochemical and Biophysical Research Communications, 358(3), 873-878. https://doi.org/10.1016/j.bbrc.2007.05.007
CR  - Zhu, W., Li, Y. H., Chen, M. L., & Hu, F. L. (2011). Protective effects of Chinese and Brazilian propolis treatment against hepatorenal lesion in diabetic rats. Human & Experimental Toxicology, 30(9), 1246-1255. https://doi.org/10.1177/0960327110387456
UR  - https://doi.org/10.31797/vetbio.1415244
L1  - https://dergipark.org.tr/en/download/article-file/3641699
ER  -