TY  - JOUR
T1  - Examining the relationship between the atherogenic index of plasma and coronary plaque burden: insights from a retrospective intravascular ultrasound analysis
TT  - Plazma aterojenik indeks ile koroner plak yükü arasındaki ilişkinin incelenmesi: retrospektif bir intravasküler ultrason grüntülerinden analizler
AU  - Erdoğan, Aslan
AU  - Özkan, Eyüp
PY  - 2024
DA  - February
Y2  - 2024
DO  - 10.47582/jompac.1421199
JF  - Journal of Medicine and Palliative Care
JO  - J Med Palliat Care / JOMPAC / Jompac
PB  - MediHealth Academy Yayıncılık
WT  - DergiPark
SN  - 2717-7505
SP  - 23
EP  - 28
VL  - 5
IS  - 1
LA  - en
AB  - Aims: In the context of coronary artery disease development, inflammation and lipid metabolism play significant roles. This study explores the link between the Atherogenic Index of Plasma (AIP) and plaque burden in intravascular ultrasound (IVUS) examined patients.Methods: A retrospective analysis included seventy-six consecutive IVUS patients from June 2020 to May 2023. AIP, calculated as the log of plasma triglyceride divided by high-density lipoprotein cholesterol, measured atherogenicity. Plaque burden, a percentage, was determined by dividing the total plaque area by the total vessel area. Multivariate regression and Spearman’s correlation analyzed the relationship between AIP and high plaque burden.Results: The median age was 59 years, with 72.4% males. Univariate analysis identified age, diabetes mellitus (DM), smoking, and AIP as plaque burden predictors. Multivariate analysis showed AIP (OR=1.53, 95% CI:1.12-2.02, p=0.021) and DM independently predicted high plaque burden (OR=1.03, 95% CI:1.01-1.45, p=0.044). Spearman’s correlation indicated a positive correlation between AIP and high plaque burden (rho: 0.682, p
KW  - Atherogenic index of plasma
KW  - coronary plaque burden
KW  - intravascular ultrasound
N2  - Amaç: Koroner arter hastalığı gelişiminde, inflamasyon ve lipid metabolizması önemli rol oynamaktadır. Bu çalışma, plazma aterojenik indeks (AIP) ve  intravasküler ultrason (IVUS) ile incelenen hastalardaki plak yükü arasındaki bağlantıyı araştırmaktadır.Materyal ve Metod:  Bu retrospektif çalışma, Haziran 2020'den Mayıs 2023'e kadar olan dönemde yapılan  yetmiş altı ardışık IVUS hastasını içermektedir. AIP, plazma trigliseridin yüksek yoğunluklu lipoprotein kolesterole bölünmesi ile  hesaplanan aterojenik bir skordur. Plak yükü, yüzde olarak, toplam plak alanının toplam damar alanına bölünmesiyle belirlendi. Çoklu regresyon ve Spearman'ın korelasyon analizi , AIP ile yüksek plak yükü arasındaki ilişkiyi analiz etmek için kullanıldı.Sonuçlar: Hastalrın ortanca yaşı 59 yıl, %72.4'ü erkekti. Univariate analizde yaş, diabetes mellitus, sigara içme ve AIP plak yükü tahmincileri olarak belirlendi. Çoklu analiz AIP'nin (OR=1.53, %95 CI: 1.12-2.02, p=0.021) ve DM'nin bağımsız olarak yüksek plak yükünü tahmin ettiğini gösterdi (OR=1.03, %95 CI: 1.01-1.45, p=0.044). Spearman'ın korelasyon analizi , AIP ve yüksek plak yükü arasında pozitif bir ilişki olduğunu gösterdi (rho: 0.682, p  < 0.05).Sonuç: Bu çalışma, aterosklerozun bir belirteci olan AIP'nin, IVUS ile incelenen hastalarda plak yükünü tahmin edebileceğini göstermektedir.
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UR  - https://doi.org/10.47582/jompac.1421199
L1  - https://dergipark.org.tr/en/download/article-file/3665939
ER  -