TY  - JOUR
T1  - Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Crimean-Congo Hemorrhagic Fever
TT  - Kırım-Kongo Kanamalı Ateşi Hastalarında Mortalitenin Belirleyicisi Olarak Laktat/Albümin Oranı
AU  - Tekin, Yusuf Kenan
AU  - Çelik, Şimşek
PY  - 2024
DA  - August
Y2  - 2024
DO  - 10.53424/balikesirsbd.1422074
JF  - Balıkesir Sağlık Bilimleri Dergisi
JO  - BAUN Health Sci J
PB  - Balıkesir University
WT  - DergiPark
SN  - 2146-9601
SP  - 339
EP  - 345
VL  - 13
IS  - 2
LA  - en
AB  - Objective:This study aimed to determine the relationship of lactate/albumin (L/A) ratio with prognosis and fatality in CCHF patients. Materials and Methods: A total of 260 patients diagnosed with CCHF between January 2019 and December 2022, 36 of whom were deceased and 224 of whom were alive, were retrospectively included in the study. The findings of survivor and non-survivor patients were compared. Results: There was no significant difference between the groups in terms of age and gender. While albumin, glucose and platelet levels were quite low in the patient group who died due to CCHF (p
KW  - Emergency Department
KW  - Crimean-Congo Hemorrhagic Fever
KW  - Lactate/Albumin Ratio
KW  - Fatality
N2  - Amaç: Bu çalışma, KKH hastalarında laktat/albümin (L / A) oranının prognoz ve mortalite ile ilişkisini belirlemeyi amaçlamıştır. Gereç ve Yöntem: Ocak 2019 ile Aralık 2022 tarihleri arasında KKH tanısı almış, 36'sı mortalite, 224'ü canlı olmak üzere toplam 260 hasta retrospektif olarak çalışmaya dahil edildi. Sağ kalan ve sağ kalan olmayan hastaların bulguları karşılaştırıldı. Bulgular: Gruplar arasında yaş ve cinsiyet açısından anlamlı fark yoktu. KKKA nedeniyle ölen hasta grubunda albumin, glukoz ve trombosit düzeyleri oldukça düşük iken (p
CR  - Appannanavar, S. B., & Mishra, B. (2011). An Update on Crimean Congo Hemorrhagic Fever. Journal of Global Infectious Diseases, 3(3),285–292. https://doi.org/10.4103/0974-777X.83537
CR  - Binici, İ., Tarcan, T., Parlak, M., İncecik, Ş., Huyut, Z., & Akbay, H. İ., et al. (2022). Kırım-Kongo kanamalı ateşi olgularının retrospektif olarak incelenmesi. Van Sag Bil Derg, 15(3),294-300. https://doi.org/10.52976/vansaglik.1192996
CR  - Bou Chebl, R., Jamali, S., Sabra, M., Safa, R., Berbari, I., & Shami, A., et al. (2020). Lactate/albumin ratio as a predictor of in-hospital mortality in septic patients presenting to the emergency department. Frontiers in Medicine (Lausanne), 22(7),550182. https://doi.org/10.3389/fmed.2020.550182. eCollection 2020.
CR  - Cakir, E., & Ozkocak Turan, I. (2021). Lactate/albumin ratio is more effective than lactate or albumin alone in predicting clinical outcomes in intensive care patients with sepsis. Scandinavian Journal of Clinical and Laboratory Investigation 81(3),225-229. https://doi.org/10.1080/00365513.2021.1901306.
CR  - Chebl, R. B., Geha, M., Assaf, M., Kattouf, N., Haidar, S., & Abdeldaem, K., et al. (2021) The prognostic value of the lactate/albumin ratio for predicting mortality in septic patients presenting to the emergency department: a prospective studys. Annals of Medicine, 53(1), 2268–2277. https://doi.org/ 10.1080/07853890.2021.2009125.
CR  - Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., & Opal, S. M. et al. (2013). Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Critical Care Medicine, 41(2),580–637. https://doi.org/10.1097/CCM.0b013e31827e83af.
CR  - Filho, R. R., Rocha, L. L., Corrêa, T. D., Pessoa Camila, M.S., Colombo, G., & Cesar Assuncao, M. S. (2016). Blood lactate levels cutoff and mortality prediction in sepsis-time for a reappraisal? A retrospective cohort study. Shock, 46(5), 480–485. https://doi.org/ 10.1097/SHK.0000000000000667
CR  - Fillâtre, P., Revest, M., & Tattevin, P. (2019). Crimean Congo hemorrhagic fever: An update. Medecine et Maladies Infectieuses, 49(8),574-585. https://doi.org/10.1016/j.medmal.2019.09.005.
CR  - Friedman, G., De Backer, D., Shahla, M., & Vincent, J. L. (1998). Oxygen supply dependency can characterize septic shock. Intensive Care Medicine, 24(2), 118–123. https://doi.org/10.1007/s001340050531.
CR  - Gharipour, A., Razavi, R., Gharipour, M., & Mukasa, D.(2020). Lactate/albumin ratio: An early prognostic marker in critically ill patients. The American journal of Emergency Medicine, 38(10), 2088–2095. https://doi.org/10.1016/j.ajem.2020.06.067.
CR  - Gul, S., Ozturk, D. B., Kisa, U., Kacmaz, B., & Yesilyurt, M. (2015). Procalcitonin Level and Its Predictive Effect on Mortality in Crimean-Congo Hemorrhagic Fever. Japanese Journal of Infectious Diseases, 68(6), 511-513. https://doi.org/10.7883/yoken.JJID.2014.485.
CR  - Hawman, D. W., & Feldmann, H. (2018). Recent advances in understanding Crimean–Congo hemorrhagic fever virüs [version 1; referees: 4 approved] F1000Research 7(F1000 Faculty Rev), 1715. https://doi.org/10.12688/f1000research.16189.1
CR  - Hawman, G. R., Buzgan, T., Irmak, H., Safran, A., Uzun, R., & Cevik, M. A., et al. The epidemiology of Crimean-Congo hemorrhagic fever in Turkey, 2002–2007. (2009). International Journal of Infectious Diseases, 13(3), 380-386 https://doi.org/10.1016/j.ijid.2008.07.021.
CR  - Kazan, F .G., & Sümer, H. (2019). Tokat il merkezinde Kırım Kongo kanamalı ateşi (KKKA) ön tanısıyla hastanede yatan hastaların, KKKA hastalığı hakkında bilgi düzeyi. Ankara Medical Journal, 19(2), 381-395. https://doi.org/10.17098/amj.576498.
CR  - Kerget, F., Kerget, B., & İba Yılmaz, S. (2021). The Association Between Procalcitonin, Lactate Level, and Clinical Prognosis in Patients with Crimean-Congo Hemorrhagic Fever. Duzce Medical Journal, 23(3), 299-304. https://doi.org/10.18678/dtfd.1012774.
CR  - Kokulu, K., & Sert, E. T. (2021). The role of the lactate/albumin ratio in predicting survival outcomes in patients resuscitated after out-of-hospital cardiac arrest: A preliminary report. The American Journal of Emergency Medicine, 50, 670-674. https://doi.org/10.1016/j.ajem.2021.09.059.
CR  - Lau, K. K., Hsiao, C. T., Fann, W. C., & Chang, C. P. (2021). Utility of the Lactate/Albumin Ratio as a Predictor for Mortality in Necrotizing Fasciitis Patients. Emergency Medicine International, 2021, 353029. https://doi.org/10.1155/2021/3530298.
CR  - Lee, J. W., You, J. S., Chung, S. P., Choa, M., Kong, T., & Ko, D. R., et al. (2019). Lactate/albumin ratio for the prediction of the development of sepsis-induced acute kidney injury in the emergency department. Journal of the Korean Society of Emergency Medicine, 30(1), 22-32. https://doi.org/10.0000/jksem.2019.30.1.22.
CR  - Lu, Y., Guo, H., Chen, X., & Zhang Q. (2021). Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis. PLoS One, 16(8), e0255744. https://doi.org/10.1371/journal.pone.0255744.
CR  - Mikkelsen, M. E., Miltiades, A. N., Gaieski, D. F., Goyal, M., Fuchs, B. D., & Shah, C. V., et al. (2009). Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Critical Care Medicine, 37(5), 1670–1677. https://doi.org/10.1097/CCM.0b013e31819fcf68.
CR  - Öngürü, P., & Bodur, H. (2012). Crimean-congo haemorrhagic fever. Journal of Experimental and Clinical Medicine, 29, 175-181. https://doi.org/10.5835/jecm.omu.29.s3.014.
CR  - Özmen, Z., & Parlak, Z. (2020). Abdominal US Findings of Crimean-Congo Hemorrhagic Fever. Journal of Contemporary Medicine, 10(2), 261-265. https://doi.org/10.16899/jcm.652354.
CR  - Shapiro, N.I., Howell, M.D., Talmor, D., Nathanson, L.A., Lisbon, A., & Wolfe, R.E., et al. (2005). Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med, 45(5), 524–528. https://doi.org/10.1016/j.annemergmed.2004.12.006.
CR  - Shin, J., Hwang, S.Y., Jo, I.J., , Kim, W.Y., Ryoo, S.M., & Kang, G.H., et al. (2018). Prognostic value of the lactate/albumin ratio for predicting 28-day mortality in critically ill sepsis patients. Shock, 50(5), 545–550.https://doi.org/10.1097/SHK.0000000000001128.
CR  - Swanepoel, R., Gill, D.E., Shepherd, A.J., Leman, P.A., Mynhardt, J.H., & Harvey, S. (1989). The Clinical Pathology of Crimean-Congo Hemorrhagic Fever. Reviews of Infectious Diseases. 11(4), 794-800. https://doi.org/10.1093/clinids/11.supplement_4.s794.
CR  - Trzeciak, S., Dellinger, R.P., Chansky, M.E., Arnold, R.C., Schorr, C., & Milcarek, B., et al. (2007). Serum lactate as a predictor of mortality in patients with infection. Intensive Care Medicine 33(6), 970–977. https://doi.org/10.1007/s00134-007-0563-9.
CR  - Wang, B., Chen, G., Cao, Y., Xue, J., Li, J., & Wu, Y. (2015). Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock. Journal of Critical Care, 30(2), 271-275. https://doi.org/10.1016/j.jcrc.2014.10.030.
Wang, R., He, M., Qu, F., Zhang, J., & Xu, J. (2022).
Lactate Albumin Ratio Is Associated with Mortality in Patients with Moderate to Severe Traumatic Brain Injury. Front Neurol, 1, 13:662385. https://doi.org/10.3389/fneur.2022.662385. eCollection 2022.
UR  - https://doi.org/10.53424/balikesirsbd.1422074
L1  - https://dergipark.org.tr/en/download/article-file/3669480
ER  -