TY - JOUR T1 - Hemodialysis Associated Methemoglobinemia: A Case Report TT - Hemodiyalize Bağlı Methemoglobinemi: Olgu Sunumu AU - Cengiz, Ayşe Nur AU - Akar, Harun PY - 2024 DA - December Y2 - 2024 DO - 10.57221/izmirtip.1423981 JF - İzmir Tıp Fakültesi Dergisi JO - İzmir Tıp Fak. Derg. PB - University of Health Sciences WT - DergiPark SN - 2822-4833 SP - 171 EP - 175 VL - 3 IS - 4 LA - en AB - Methemoglobin is a non-functional type of hemoglobin that forms as a result of the oxidation of iron from the ferrous form (+2) to the ferric form (+3). While normal individuals have methemoglobin levels between 1-2%, in patients with methemoglobinemia, tissue perfusion can be severely compromised, with levels of 70% or higher leading to fatal outcomes. In this case,we present the management of a patient refered from emergency department with cyanosis and diagnosed with methemoglobinemia. KW - methemoglobinemia KW - chronic kidney disease KW - hemodialysis N2 - Methemoglobin fonksiyonel olmayan bir hemoglobin tipi olup demirin ferröz formundan (+2) ferrik forma (+3) oksidasyonu sonucu oluşur. Normal bireylerde methemoglobin düzeyi %1-2 arası iken methemoglobinemisi olan hastalarda %70 ve üzerinde doku perfüzyonunun bozulmasına bağlı ölümcül seyredebilir. Bu olgu sunumunda acil servise periferik ve santral siyanoz ile başvuran methemoglobinemi saptanan hastanın dahili açıdan yönetimi anlatılacaktır CR - 1. Prchal JT. Methemoglobinemia and other dyshemoglobinemias. Chap 51. In: Williams Hematology, 10th ed, Kaushansky K, Litchtman MA, Prchal JT, et al (Eds), McGraw Hill, New York 2021. p.859. CR - 2. Jaffe E, Hultquist D. Cytochrome b5 reductase deficiency and enzymopenic hereditary methemoglobinemia. In: The metabolic and molecular bases of inherited disease, 7th ed, Scriver C, Beaudet A, Sly W, Valle D (Eds), McGraw Hill, New York 1995. Vol 3, p.3399. CR - 3. Nakata M, Yokota N, Tabata K, Morikawa T, Shibata H, Kenzaka T. Hereditary congenital methemoglobinemia diagnosed at the age of 79 years: a case report. Medicina (Kaunas). 2023;59:615. CR - 4. Meslek hastalıkları ve işle ilgili hastalıklar tanı rehberi. Çalışma ve Sosyal Güvenlik Bakanlığı. https://www.csgb.gov.tr/medias/4597/rehber20.pdf CR - 5. Sahu KK, Lal A, Mishra A, George S. Food poisoning associated methemoglobinemia: time to wake up. World J Emerg Med. 2020;11:127-8. CR - 6. Greenberg KI, Choi MJ. Hemodialysis emergencies: core curriculum. Am J Kidney Dis. 2021;77:796-809. 7. Cefalu JN, Joshi TV, Spalitta MJ, Kadi CJ, Diaz JH, Eskander JP, et al. Methemoglobinemia in the operating room and ıntensive care unit: early recognition, pathophysiology, and management. Adv Ther. 2020;37:1714-23. CR - 8. De Torres JP, Strom JA, Jaber BL, Hendra KP. Hemodialysis-associated methemoglobinemia in acute renal failure. Am J Kidney Dis. 2002;39:1307-9. CR - 9. Skold A, Cosco DL, Klein R. Methemoglobinemia: pathogenesis, diagnosis, and management. South Med J. 2011;104:757-61. CR - 10. Elmas B, Koçer GB, Özdemir Ö. İntravenöz askorbik asid ile birlikte oral metilen mavisi kullanılan, prilokaine bağlı methemoglobinemi: vaka takdimi. Sakarya Tıp Dergisi. 2016;6:245-8. CR - 11. Chávez-Iñiguez JS, Medina-González R, Ron-Magaña A, Madero M, Ramírez-Ramírez AC, Rifkin BS, et al. Methemoglobinemia in hemodialysis patients due to acute chlorine ıntoxication: a case series calling attention on an old problem. Blood Purif. 2023;52:835-43. CR - 12. Medarov BI, Pahwa S, Reed S, Blinkhorn R, Rane N, Judson MA. Methemoglobinemia caused by portable dialysis in the critically ill. Crit Care Med. 2017;45:e232-5. CR - 13. Gok M, Aydemir YG. Methemoglobinemia in pregnancy with chronic kidney disease an uncommon case: a case report. J Pak Med Assoc. 2022;72:363-65. CR - 14. Torabi J, Campbell A, Nair G, Patel GL, Miura Y, Graham JA. Dapsone-induced methemoglobinemia in two renal transplant recipients. Prog Transplant. 2019;29:289-90. UR - https://doi.org/10.57221/izmirtip.1423981 L1 - https://dergipark.org.tr/en/download/article-file/3677167 ER -